Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1392
Gene Symbol: CRH
CRH 		0.300 Biomarker disease CTD_human Brain corticotropin-releasing factor mediates 'anxiety-like' behavior induced by cocaine withdrawal in rats. 7796157 1995
Entrez Id: 3351
Gene Symbol: HTR1B
HTR1B 		0.500 Biomarker disease CTD_human Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. 9603521 1998
Entrez Id: 3351
Gene Symbol: HTR1B
HTR1B 		0.500 Therapeutic disease CTD_human Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. 9603521 1998
Entrez Id: 887
Gene Symbol: CCKBR
CCKBR 		0.300 Biomarker disease CTD_human Thus, a potential therapeutic role for CCK-A antagonists in the treatment of ethanol abuse and for CCK-B antagonists in the treatment of cocaine abuse is proposed. 9922984 1998
Entrez Id: 9607
Gene Symbol: CARTPT
CARTPT 		0.510 Biomarker disease PSYGENET The role of dopamine, dynorphin, and CART systems in the ventral striatum and amygdala in cocaine abuse. 10415667 1999
Entrez Id: 1392
Gene Symbol: CRH
CRH 		0.300 Biomarker disease CTD_human A role for the bed nucleus of the stria terminalis, but not the amygdala, in the effects of corticotropin-releasing factor on stress-induced reinstatement of cocaine seeking. 10516337 1999
Entrez Id: 1814
Gene Symbol: DRD3
DRD3 		0.500 Biomarker disease CTD_human Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence. 10523822 1999
Entrez Id: 1814
Gene Symbol: DRD3
DRD3 		0.500 Therapeutic disease CTD_human Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence. 10523822 1999
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3 		0.520 Biomarker disease PSYGENET The effects of chronic cocaine abuse on transcriptional regulation of human dopamine transporter (DAT) mRNA in midbrain dopaminergic neurons was assessed by reverse transcription-polymerase chain reaction (RT-PCR). 10581411 1999
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.540 Biomarker disease CTD_human Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists. 10900248 2000
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.540 Therapeutic disease CTD_human Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists. 10900248 2000
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A 		0.300 Biomarker disease CTD_human Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats. 11259563 2001
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3 		0.520 Therapeutic disease CTD_human Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. 11320258 2001
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3 		0.520 Biomarker disease CTD_human Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. 11320258 2001
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4 		0.310 Biomarker disease CTD_human Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. 11320258 2001
Entrez Id: 1385
Gene Symbol: CREB1
CREB1 		0.300 Biomarker disease CTD_human Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse. 11717377 2001
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3 		0.520 Biomarker disease CTD_human Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. 11746736 2002
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3 		0.520 Therapeutic disease CTD_human Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. 11746736 2002
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker disease CTD_human Temporal concordance of cocaine effects on mood states and neuroendocrine hormones. 11750770 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.540 Therapeutic disease CTD_human Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. 11751029 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.540 Biomarker disease CTD_human Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. 11751029 2002
Entrez Id: 1392
Gene Symbol: CRH
CRH 		0.300 Biomarker disease CTD_human A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats. 11797056 2001
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A 		0.300 Biomarker disease CTD_human These findings point to a potential role for 5-HT1A antagonists in treatment of cocaine abuse. 11853856 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.540 Therapeutic disease CTD_human Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. 11923462 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.540 Biomarker disease CTD_human Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. 11923462 2002