Gene: BRAF ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth. 23812671 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 Biomarker group CTD_human Microsatellite instability: an update. 25701956 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis. 20857202 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. 20619739 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE These findings do not support testing stage I or II colorectal tumors for BRAF mutations, although additional large studies are needed. 29660527 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. 22535154 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms. 15729718 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 Biomarker group BEFREE In this study, 40 wild type KRAS and BRAF colorectal tumors were analyzed to elucidate whether PML-RARa bcr1 fusion gene may play a role in colorectal carcinogenesis. 22167334 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer. 18757341 2008
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. 19794125 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE To verify the technical characteristics of the microarray system for the correct identification of the KRAS mutational status at the two hotspot codons 12 and 13 and of the BRAF(V600E) mutation in colorectal tumor, we selected 75 samples previously characterized by conventional and CO-amplification at Lower Denaturation temperature-PCR (COLD-PCR) followed by High Resolution Melting analysis and direct sequencing. 23536897 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer. 17195912 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE The LR in favor of pathogenicity was estimated to be ~12-fold for a colorectal tumor with a BRAF mutation-negative MSI-H phenotype. 22949379 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF as a target for cancer therapy. 21426297 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE The major aim of this study was to evaluate the performance of anti-BRAF V600E (VE1) antibody in colorectal tumors with and without KRAS mutation. 29127628 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. 22281684 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE Vemurafenib doesn't shrink BRAF-mutated colorectal tumors, but a regimen that also includes irinotecan and cetuximab improves vemurafenib's effectiveness, more than doubling progression-free survival in patients with metastatic tumors. 28153858 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer. 15765445 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE We did not detect BRAF mutations in patients with double somatic colorectal tumors or Lynch syndrome. 27302833 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE Recently, a V599E hotspot mutation within the BRAF gene was reported in a high percentage of colorectal tumors and significantly associated to defective mismatch repair (MMR). 14668801 2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE Immunohistochemical detection of the BRAF V600E mutant protein in colorectal neoplasms. 25517872 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. 22180495 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. 21163703 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 Biomarker group BEFREE TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors. 25239454 2014