Gene: BRAF ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE Here we perform an extensive characterization of BRAF mutations in a large series of colorectal tumors in various stages of neoplastic transformation. 12438234 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Mutations of the BRAF gene in human cancer. 12068308 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. 12198537 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE Recently, a V599E hotspot mutation within the BRAF gene was reported in a high percentage of colorectal tumors and significantly associated to defective mismatch repair (MMR). 14668801 2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 AlteredExpression group BEFREE Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. 14678966 2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE Activating mutations of BRAF were reported recently in most melanomas and a small proportion of colorectal tumors. 12670889 2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 PosttranslationalModification group LHGDN Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas. 14639609 2004
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular transformation. 15150094 2004
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 PosttranslationalModification group LHGDN BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. 15489648 2004
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. 14734469 2004
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms. 15729718 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer. 15765445 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE Alterations of BRAF have been implicated in the carcinogenesis of colorectal tumors with microsatellite instability (MSI). 16015629 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN To evaluate the role of oncogenic BRAF mutations in non-hereditary nonpolyposis colorectal cancer/non-familial adenomatous polyposis familial colorectal cancer, we did a mutation screening of the most common BRAF mutation, the V600E mutation, in 194 colorectal tumors from patients with a positive family history of the disease. 17119056 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers. 16918136 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. 16804544 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE The aim of the present study was to evaluate the clinical, pathological and molecular phenotype of colorectal tumors with BRAF mutations. 16403224 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer. 17195912 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. 16953233 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma. 17663506 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. 17699719 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer. 17393356 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. 17440063 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group LHGDN Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer. 18757341 2008
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 Biomarker group CTD_human Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. 18718023 2008