Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Therefore, we investigated whether salivary levels of MMP-9 and MPO corresponded to plasma levels in patients with coronary artery disease (CAD), both at rest and after acute physical exercise. 30726210 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE The level of MMP-9 was significantly higher in COPD patients with >3 comorbidities, a COTE index of ≥4 and cardiovascular disease as well as coronary heart disease (t=6.40, 2.53, 3.65 and 2.90, P<0.05). 30542429 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association between matrix metalloproteinase 9 C-1562T polymorphism and the risk of coronary artery disease: an update systematic review and meta-analysis. 29507703 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Furthermore, omega-6 fatty acids significantly downregulated MMP-2 and MMP-9 expression in our coronary heart disease-induced rat model. 30443948 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease. 28390432 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Role of serum MMP-9 levels and vitamin D receptor polymorphisms in the susceptibility to coronary artery disease: An association study in Iranian population. 28739397 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Plasma concentration, genetic variation, and gene expression levels of matrix metalloproteinase 9 in Iranian patients with coronary artery disease. 28400830 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Relationship between serum cytokines receptors and matrix metalloproteinase 9 levels and coronary artery disease. 27910999 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE In conclusion, we suggest that the TT and CT genotypes and T allele of MMP-9 rs3918242 polymorphism is correlated with an increased risk of coronary artery disease in a Chinese population. 27323016 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Therapeutic disease RGD Rat coronary atherosclerosis heart disease model can be successfully established by feeding with high-fat diet and intraperitoneal injection of VD3, the permeability of coronary artery in coronary heart disease rat model is significantly increased, which may be related to up-regulation of MMP-9, CD40L, TNF-α and CRP expression. 26261622 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis. 24599689 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases the risk of clinical events in patients with coronary artery disease. 25191702 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association between -1562C>T polymorphism in the promoter region of matrix metalloproteinase-9 and coronary artery disease: a meta-analysis. 24506511 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association of genetic polymorphisms in matrix metalloproteinase-9 and coronary artery disease in the Chinese Han population: a case-control study. 23819814 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Meta-analysis of MMP9-562C/T and the risk of coronary heart disease. 23328249 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE The co-existence of the IL-18+183 A/G and MMP-9 -1562 C/T polymorphisms is associated with clinical events in coronary artery disease patients. 24040261 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Matrix metalloproteinase-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease. 21559835 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Genetic variation, gene-expression and circulating levels of matrix metalloproteinase-9 in patients with stable coronary artery disease. 21963461 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association of matrix metalloproteinases (MMP2, MMP7 and MMP9) genetic variants with left ventricular dysfunction in coronary artery disease patients. 22664146 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE It has been observed that increased MMP-9 expression in T allele carriers may contribute to the severity of coronary atherosclerosis. 22809399 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Serum MMP-9 levels may therefore represent a novel marker of inflammation in patients with known coronary artery disease. 19576641 2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population. 19283512 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE The observation indicates that the polymorphisms in the MMP-9 and PON1 192 genes potentially play a role in the manifestation of coronary atherosclerosis but does not have any effect on the number of diseased vessels in Iran. 20872564 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Circulating concentrations of matrix metalloproteinase 9 (MMP-9) are associated with cardiovascular disease mortality in patients with coronary artery disease. 20184534 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Lack of association between matrix metalloproteinase-9 and endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in Turkish population. 19435423 2009