Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE A total of 84 children and adolescents were assessed for fasting total homocysteine, methylenetetrahydrofolate reductase polymorphism (C677T mutation), folate and vitamin B12 status, and anthropometric and metabolic risk factors for CHD. 10977031 2000
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. 28408323 2018
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE The significant correlations of Lpa and total sialic acid with glycated haemoglobin, lipoproteins and apolipoproteins partially explain reporting them as possible markers for coronary heart disease. 16258736 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Association of apolipoprotein E genotype with early onset of coronary heart disease in Greek men. 16327942 2006
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls. 15612980 2005
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E alleles are important genetic markers for dyslipidemia and CHD. 7966894 1994
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index. 26188224 2016
Entrez Id: 7941
Gene Symbol: PLA2G7
PLA2G7
0.500 GeneticVariation disease BEFREE Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. 15115767 2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE MTHFR rs1801131 were identified as loci in Chinese population that were involved in CHD. 26035828 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E (apo E) polymorphism is a genetic determinant of lipid and lipoprotein levels and the risk for coronary heart disease. 10094101 1999
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 AlteredExpression disease BEFREE An elevated plasma level of apolipoprotein B (apoB), the major protein of low density lipoproteins, is a risk factor for coronary artery disease. 8349099 1993
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Meta-analysis of low density lipoprotein receptor (LDLR) rs2228671 polymorphism and coronary heart disease. 24900971 2015
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 AlteredExpression disease BEFREE The relation of LDL receptor activity to lipoprotein(a) plasma concentration in patients without coronary artery disease. 8187228 1994
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)). 22042884 2012
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Among the 57 mothers of CHD-affected children with DS who carried the MTHFR 677CT or TT genotypes and did not have periconceptional folic acid intake, we observed a 2.26-fold increased odds (95% CI 1.25-4.09) of having any CHD-affected child with DS. 19725133 2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity. 18403793 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E polymorphism and coronary artery disease. 6882285 1983
Entrez Id: 7941
Gene Symbol: PLA2G7
PLA2G7
0.500 GeneticVariation disease BEFREE Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart disease: a meta-analysis. 21107710 2011
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE Lipoprotein(a) [Lp(a)] is a macromolecular complex found in human plasma that combines structural elements from the lipoprotein and blood clotting systems and that is associated with premature coronary heart disease and stroke. 2530631 1989
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus. 20605575 2010
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE Genetic variants of apolipoprotein B: relation to serum lipid levels and coronary artery disease among the Finns. 1418918 1992
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Hyperhomocysteinaemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease. 16704755 2006
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE In a group of 110 subjects with severe coronary artery disease, two were heterozygous for the apolipoprotein (apo) B arginine3,500----glutamine mutation that characterizes familial defective apo B-100. 1671822 1991
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 Biomarker disease BEFREE Persons with hFH generally manifest elevations of low density lipoprotein (LDL) cholesterol throughout their lives and have a markedly increased risk of death from coronary artery disease. 8105671 1993
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE The exceptionally low frequency of MTHFR mutant homozygotes in this population suggests that this polymorphism should not be regarded as an important CHD risk factor among Black South Africans. 10428303 1999