Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 940
Gene Symbol: CD28
CD28
0.030 GeneticVariation disease BEFREE CHD in Chinese population is strongly associated with HLA-DRB1*01 and DRB1*04 haplotypes, and formation of CD4(+)CD28(null) T cells was related to HLA-DRB1*01, DRB1*04, and DRB1*15 alleles. 20842443 2011
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.100 GeneticVariation disease BEFREE Coronary artery disease risk alleles downstream of CXCL12 are associated with plasma protein levels of CXCL12 and appear to be related to CXCL12 transcript levels in two human cell lines. 21415067 2011
Entrez Id: 5950
Gene Symbol: RBP4
RBP4
0.050 Biomarker disease BEFREE Coronary artery disease is associated with higher epicardial retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue. 21645024 2012
Entrez Id: 3240
Gene Symbol: HP
HP
0.100 GeneticVariation disease BEFREE Coronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin. 22098782 2011
Entrez Id: 5616
Gene Symbol: PRKY
PRKY
0.010 AlteredExpression disease BEFREE Coronary artery disease predisposing haplogroup I of the Y chromosome is associated with downregulation of UTY and PRKY genes in macrophages but not with conventional cardiovascular risk factors. 23640493 2013
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.030 GeneticVariation disease BEFREE CHD cases (n=560) and randomly selected population controls (n=2791) were genotyped at 58 SNPs in the NOS genes. 24713495 2014
Entrez Id: 55349
Gene Symbol: CHDH
CHDH
0.100 GeneticVariation disease BEFREE Coronary heart disease (CHD) genetic tests are increasingly available through direct-to-consumer marketing, but their potential clinical impact on cardiovascular risk assessment is unclear. 25797277 2015
Entrez Id: 6943
Gene Symbol: TCF21
TCF21
0.190 Biomarker disease BEFREE Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. 26020946 2015
Entrez Id: 84830
Gene Symbol: ADTRP
ADTRP
0.140 Biomarker disease BEFREE Coronary artery disease susceptibility gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by global gene expression regulation. 27235449 2016
Entrez Id: 1667
Gene Symbol: DEFA1
DEFA1
0.020 AlteredExpression disease BEFREE CHD development moderately correlated with α-defensin mRNA expression (r = 0.429, p = 0.023) and with plasma HNP 1-3 levels (r = 0.486, p = 0.000). 27430968 2016
Entrez Id: 574045
Gene Symbol: HNP1
HNP1
0.010 AlteredExpression disease BEFREE CHD development moderately correlated with α-defensin mRNA expression (r = 0.429, p = 0.023) and with plasma HNP 1-3 levels (r = 0.486, p = 0.000). 27430968 2016
Entrez Id: 728358
Gene Symbol: DEFA1B
DEFA1B
0.010 AlteredExpression disease BEFREE CHD development moderately correlated with α-defensin mRNA expression (r = 0.429, p = 0.023) and with plasma HNP 1-3 levels (r = 0.486, p = 0.000). 27430968 2016
Entrez Id: 221692
Gene Symbol: PHACTR1
PHACTR1
0.200 GeneticVariation disease BEFREE Coronary artery disease associated gene Phactr1 modulates severity of vascular calcification in vitro. 28720499 2017
Entrez Id: 7403
Gene Symbol: KDM6A
KDM6A
0.010 GeneticVariation disease BEFREE CHD was diagnosed in 19/27 (70%) patients with KMT2D (MLL2) variant, while the single patient with KDM6A change had a normal heart. 28884922 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE CHD was diagnosed among 114 residents (60.3%) but only 60.5% of them were treated with aspirin (ASA), 45.6% with beta-blockers (BBs), 60.5% with angiotensin-converting enzyme inhibitor (ACEI), and 24.6% with statins. 29402648 2018
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). 29713054 2018
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein(a) (Lp(a)), a low-density lipoprotein-like particle distinguished by the presence of the glycoprotein apolipoprotein(a) (apo(a)), which is bound to apolipoprotein B-100 (apoB-100) by disulfide bridges. 2976021 1988
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein(a) (Lp(a)), a low-density lipoprotein-like particle distinguished by the presence of the glycoprotein apolipoprotein(a) (apo(a)), which is bound to apolipoprotein B-100 (apoB-100) by disulfide bridges. 2976021 1988
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
0.140 GeneticVariation disease BEFREE Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. 30307970 2018
Entrez Id: 6943
Gene Symbol: TCF21
TCF21
0.190 GeneticVariation disease BEFREE Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. 30307970 2018
Entrez Id: 28
Gene Symbol: ABO
ABO
0.200 Biomarker disease BEFREE Coronary Heart Disease and ABO Blood Group in Diabetic Women: A Case-Control Study. 31092877 2019
Entrez Id: 7292
Gene Symbol: TNFSF4
TNFSF4
0.040 Biomarker disease BEFREE Coronary heart disease is related to sudden death caused by multi-factors and a major threat to human health.This study explores the role of OX40L and ICAM-1 in the stability of coronary plaques and their relationship with sudden coronary death. 31783796 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.100 Biomarker disease BEFREE Coronary heart disease is related to sudden death caused by multi-factors and a major threat to human health.This study explores the role of OX40L and ICAM-1 in the stability of coronary plaques and their relationship with sudden coronary death. 31783796 2019
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Coronary artery disease in heterozygous familial hypercholesterolemia patients with the same LDL receptor gene mutation. 7634440 1995
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 Biomarker disease BEFREE Coronary heart disease was more common in MODY3 than in IDDM (16 vs 4.5%; p < 0.02) but less common than in the older NIDDM patients (33.3%; p < 0.02). 9562352 1998