| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.300 | Biomarker | phenotype | CTD_human | In mouse brain, PRRX1 mRNA was detected in non-dividing OPCs and is upregulated in OPCs following demyelination. | 30566868 | 2018 | ||||
|
0.300 | Therapeutic | phenotype | CTD_human | SIRT1 suppressed EAE clinical symptoms compared with wild-type EAE mice and prevented or altered the phenotype of inflammation in spinal cords; as a result, demyelination and axonal injury were reduced. | 23547115 | 2013 | ||||
|
0.300 | Biomarker | phenotype | CTD_human | Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model. | 23360710 | 2013 | ||||
|
0.300 | Biomarker | phenotype | CTD_human | Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets. | 23547115 | 2013 | ||||
|
0.300 | Biomarker | phenotype | CTD_human | Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice. | 20739560 | 2010 | ||||
|
0.300 | Biomarker | phenotype | CTD_human | In this study, we used the cuprizone model of demyelination, characterized by oligodendrogliopathy and microglial infiltration, to define the effect of p53 inhibition. | 18550754 | 2008 | ||||
|
0.300 | Therapeutic | phenotype | CTD_human | Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice. | 9452187 | 1997 | ||||
|
0.300 | Biomarker | phenotype | CTD_human | In the present study we have examined the MATA1 gene of eight hypermethioninemic individuals, including the two with demyelination of the brain. | 8770875 | 1996 | ||||
|
0.300 | Biomarker | phenotype | CTD_human | High-dose methotrexate-induced neurotoxicity associated with elevation of CSF myelin basic protein. | 2580064 | 1985 | ||||
|
0.200 | Biomarker | phenotype | CTD_mouse | A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination. | 16245024 | 2005 |