Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1523
Gene Symbol: CUX1
CUX1
0.010 Biomarker phenotype BEFREE Based on the PRVEP findings, it may be concluded that migraineurs have sensitization of P100 and impaired habituation of N75 especially during headache. 28974100 2018
Entrez Id: 9733
Gene Symbol: SART3
SART3
0.010 Biomarker phenotype BEFREE Based on the PRVEP findings, it may be concluded that migraineurs have sensitization of P100 and impaired habituation of N75 especially during headache. 28974100 2018
Entrez Id: 22974
Gene Symbol: TPX2
TPX2
0.010 Biomarker phenotype BEFREE Based on the PRVEP findings, it may be concluded that migraineurs have sensitization of P100 and impaired habituation of N75 especially during headache. 28974100 2018
Entrez Id: 27044
Gene Symbol: SND1
SND1
0.010 Biomarker phenotype BEFREE Based on the PRVEP findings, it may be concluded that migraineurs have sensitization of P100 and impaired habituation of N75 especially during headache. 28974100 2018
Entrez Id: 84164
Gene Symbol: ASCC2
ASCC2
0.010 Biomarker phenotype BEFREE Based on the PRVEP findings, it may be concluded that migraineurs have sensitization of P100 and impaired habituation of N75 especially during headache. 28974100 2018
Entrez Id: 8408
Gene Symbol: ULK1
ULK1
0.010 AlteredExpression phenotype BEFREE By restraining UNC-51 activity, RPM-1 inhibits autophagosome formation to affect axon termination, synapse maintenance and behavioral habituation. 31676756 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.300 Biomarker phenotype CTD_human Chronic unpredictable stress enhances cocaine-conditioned place preference in type 1 cannabinoid receptor knockout mice. 18690112 2008
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.030 Biomarker phenotype BEFREE Collectively, the data presented demonstrate that HIV-1 proteins accelerate habituation to repeated stressors and modify the influence of acute and repeat stressors on GR co-chaperones in a brain region-specific manner. 25666308 2015
Entrez Id: 3060
Gene Symbol: HCRT
HCRT
0.020 Biomarker phenotype BEFREE Collectively, these results indicate that the OX<sub>2</sub>R plays a role in acute stress, and can prevent habituation to repeated stress under conditions of high orexin release. 28257896 2017
Entrez Id: 57634
Gene Symbol: EP400
EP400
0.010 Biomarker phenotype BEFREE Compared to infants who only received assessment and monitoring, infants who received the intervention showed improvements in neurocognitive metrics of social attention, as reflected in a greater reduction in habituation times to face versus object stimuli between 6 and 12 months, maintained at 18 months; a greater increase in frontal EEG theta power between 6 and 12 months; and a more comparable P400 response to faces and objects at 12 months. 28244271 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.020 Biomarker phenotype BEFREE Considering the MTHFR genotype in migraine patients and controls, the C677TT subjects exhibited a reduced habituation index of the early CNV (iCNV), in respect with both C677TC and C677CC; in the migraine group, there was a significant decrease of CNV habituation in patients with homozygosis and a positive correlation between the habituation index values and the homocysteine levels. 17300365 2007
Entrez Id: 2166
Gene Symbol: FAAH
FAAH
0.310 GeneticVariation phenotype BEFREE Consistent with this, carriers of a low-expressing FAAH variant (385A allele; rs324420) exhibited quicker habituation of amygdala reactivity to threat, and had lower scores on the personality trait of stress-reactivity. 22688188 2013
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.030 AlteredExpression phenotype BEFREE Control (sham) and fracture (TF) groups were followed to determine nitrite/nitrate concentration; oxidative damage to lipids and proteins; the activity of antioxidant enzymes (superoxide dismutase-SOD and catalase-CAT), mitochondrial respiratory chain enzymes, and creatine kinase (CK); and BDNF levels in the hippocampus and prefrontal cortex (at 24 h and at seven days) and cognitive function through habituation to the open field task and novel object recognition task (only at seven days). 30041011 2018
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.020 Biomarker phenotype BEFREE CORT feedback has little effect on CRH neuron responses to acute stress, or on habituation to repeated stressors. 31836701 2019
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.020 GeneticVariation phenotype BEFREE Depletion of brain 5-HT in Tph2 mutant mice resulted in reduced behavioural despair, reduced anxiety, marked aggression and lower habituation in novel environments, reminiscent of bipolar-associated manic behaviour. 30087403 2018
Entrez Id: 57556
Gene Symbol: SEMA6A
SEMA6A
0.010 Biomarker phenotype BEFREE Disruption to the axonal guidance and cell migration processes regulated by Sema6A is associated with topographically specific disruption to fundamental aspects of behaviour, namely the ethogram of initial exploration and subsequent habituation to the environment, and motor learning. 28109776 2017
Entrez Id: 2166
Gene Symbol: FAAH
FAAH
0.310 Biomarker phenotype CTD_human Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. 19103437 2009
Entrez Id: 84650
Gene Symbol: EBPL
EBPL
0.010 GeneticVariation phenotype BEFREE Does pain hypervigilance further impact the lack of habituation to pain in individuals with chronic pain? A cross-sectional pain ERP study. 29497330 2018
Entrez Id: 2004
Gene Symbol: ELK3
ELK3
0.010 GeneticVariation phenotype BEFREE Does pain hypervigilance further impact the lack of habituation to pain in individuals with chronic pain? A cross-sectional pain ERP study. 29497330 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.020 GeneticVariation phenotype BEFREE Experiment 3 tested whether prior habituation to restraint (5 days) would alter the IL-1β response evoked by swim exposure imposed immediately after the sixth day of restraint. 28803453 2017
Entrez Id: 952
Gene Symbol: CD38
CD38
0.010 AlteredExpression phenotype BEFREE Exploratory sub-group analyses for severely ill patients and patients with high anxiety and strong habituation during exposure showed that DCS administration was associated with increased improvement during the 1-month follow-up period (t10 - t11) with medium to large effect sizes (range in effect size η<sup>2</sup><sub>p</sub> from .06 to .25). 30237105 2018
Entrez Id: 3176
Gene Symbol: HNMT
HNMT
0.010 AlteredExpression phenotype BEFREE Finally, lentiviral vectors were microinjected into the DVC to determine the effects of altered HNMT expression on MS. We found the following: 1) HNMT expression in the medulla oblongata of dogs and rats insusceptible to MS was higher than in susceptible animals; 2) tacrine dose-dependently promoted MS in both animals and raised histamine level in rat medulla oblongata; 3) blocking histaminergic neurotransmission in the DVC with promethazine inhibited MS; 4) rotatory stimulus induced an elevation in HNMT expression, and vestibular training elevated the basal level of HNMT in the DVC during habituation to MS; 5) in vivo transfection of a lentiviral vector packaged with the HNMT gene increased HNMT expression in the DVC and reduced MS; and 6) microinjection of a lentiviral vector driving the interference of HNMT gene expression in vivo significantly inhibited HNMT expression in the DVC and exacerbated MS. 29298819 2018
Entrez Id: 84902
Gene Symbol: CEP89
CEP89
0.010 Biomarker phenotype BEFREE Finally, we tested neuronal Cep89 knockdown flies in the light-off jump reflex habituation assay, which revealed its role in learning. 23575228 2013
Entrez Id: 5443
Gene Symbol: POMC
POMC
0.030 GeneticVariation phenotype BEFREE Furthermore, a weak habituation was related to low cortisol responses to both the first stress exposure as well as the ACTH challenge. 15471617 2005
Entrez Id: 2915
Gene Symbol: GRM5
GRM5
0.310 Biomarker phenotype CTD_human Genome wide association for addiction: replicated results and comparisons of two analytic approaches. 20098672 2010