×
Entrez Id:
5617
Gene Symbol:
PRL
PRL
0.320
GeneticVariation
group
BEFREE
The most frequently reported were ADRs related to extrapyramidal syndrome (14.7%), breast disorders or blood prolactin level changes (4.7%), and cardiac arrhythmias (4.6%).
30676073
2019
×
Entrez Id:
5617
Gene Symbol:
PRL
PRL
0.320
Biomarker
group
BEFREE
Our findings demonstrate that there is moderate to high level of evidence suggesting that in the treatment of schizophrenia, LAI SGAs have higher efficacy and are associated with higher rates of extrapyramidal syndrome and prolactin -related symptoms.
30466208
2018
×
Entrez Id:
5617
Gene Symbol:
PRL
PRL
0.320
Biomarker
group
CTD_human
Clinical state, plasma levels of haloperidol and prolactin: a correlation study in chronic schizophrenia.
7214106
1980
×
Entrez Id:
1813
Gene Symbol:
DRD2
DRD2
0.310
Biomarker
group
CTD_human
A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms.
19506579
2009
×
Entrez Id:
1813
Gene Symbol:
DRD2
DRD2
0.310
Biomarker
group
CTD_human
Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms.
19225277
2009
×
Entrez Id:
1813
Gene Symbol:
DRD2
DRD2
0.310
Biomarker
group
CTD_human
Aripiprazole-induced parkinsonism and its association with dopamine and serotonin receptor polymorphisms.
18480698
2008
×
Entrez Id:
1813
Gene Symbol:
DRD2
DRD2
0.310
GeneticVariation
group
BEFREE
Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.
16867246
2006
×
Entrez Id:
1565
Gene Symbol:
CYP2D6
CYP2D6
0.310
Biomarker
group
CTD_human
Delirium resolving upon switching from risperidone to quetiapine: implication of CYP2D6 genotype.
16000684
2005
×
Entrez Id:
1813
Gene Symbol:
DRD2
DRD2
0.310
Biomarker
group
CTD_human
Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy.
12211096
2002
×
Entrez Id:
1565
Gene Symbol:
CYP2D6
CYP2D6
0.310
GeneticVariation
group
BEFREE
Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: a case-control study.
11927839
2002
×
Entrez Id:
1813
Gene Symbol:
DRD2
DRD2
0.310
Biomarker
group
CTD_human
D2 receptor occupancy under recommended and high doses of olanzapine: an iodine-123-iodobenzamide SPECT study.
11198054
2000
×
Entrez Id:
5155
Gene Symbol:
PDGFB
PDGFB
0.300
Biomarker
group
CTD_human
Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export.
25938945
2015
×
Entrez Id:
9213
Gene Symbol:
XPR1
XPR1
0.300
Biomarker
group
CTD_human
Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export.
25938945
2015
×
Entrez Id:
5159
Gene Symbol:
PDGFRB
PDGFRB
0.300
Biomarker
group
CTD_human
Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export.
25938945
2015
×
Entrez Id:
6575
Gene Symbol:
SLC20A2
SLC20A2
0.300
Biomarker
group
CTD_human
Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export.
25938945
2015
×
Entrez Id:
10367
Gene Symbol:
MICU1
MICU1
0.300
Biomarker
group
CTD_human
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.
24336167
2014
×
Entrez Id:
8622
Gene Symbol:
PDE8B
PDE8B
0.300
Biomarker
group
CTD_human
Autosomal-dominant striatal degeneration is caused by a mutation in the phosphodiesterase 8B gene.
20085714
2010
×
Entrez Id:
1814
Gene Symbol:
DRD3
DRD3
0.300
Biomarker
group
CTD_human
A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms.
19506579
2009
×
Entrez Id:
80704
Gene Symbol:
SLC19A3
SLC19A3
0.300
Biomarker
group
CTD_human
Mutations in a thiamine-transporter gene and Wernicke's-like encephalopathy.
19387023
2009
×
Entrez Id:
3356
Gene Symbol:
HTR2A
HTR2A
0.300
Biomarker
group
CTD_human
Aripiprazole-induced parkinsonism and its association with dopamine and serotonin receptor polymorphisms.
18480698
2008
×
Entrez Id:
151056
Gene Symbol:
PLB1
PLB1
0.010
GeneticVariation
group
BEFREE
Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively.
21496576
2011
×
Entrez Id:
80025
Gene Symbol:
PANK2
PANK2
0.010
GeneticVariation
group
BEFREE
Mutations in pantothenate kinase 2 (PANK2 ) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively.
21496576
2011
×
Entrez Id:
5319
Gene Symbol:
PLA2G1B
PLA2G1B
0.010
GeneticVariation
group
BEFREE
Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively.
21496576
2011
×
Entrez Id:
8398
Gene Symbol:
PLA2G6
PLA2G6
0.010
GeneticVariation
group
BEFREE
Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6 ) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively.
21496576
2011
×
Entrez Id:
7534
Gene Symbol:
YWHAZ
YWHAZ
0.010
GeneticVariation
group
BEFREE
Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively.
21496576
2011