Lipid A of ΔPGN_1123 mutants is penta-acylated and devoid of tetra-acylated structures, and the mutant strain provokes a strong TLR4-mediated proinflammatory response, in contrast to the negligible response elicited by wild-type <i>P. gingivalis</i> Heterologous expression of PGN_1123 in <i>Bacteroides thetaiotaomicron</i> promoted lipid A deacylation, confirming that PGN_1123 encodes the lipid A deacylase enzyme.<b>IMPORTANCE</b> Periodontitis, commonly referred to as gum disease, is a chronic inflammatory condition that affects a large proportion of the population.
The hypermethylation frequencies of TIMP-3 and GSTP-1 of reversible chronic inflammatory gum disease and the control group were similar, but both were significantly lower than those for malignant disease patients (p<0.0001).
The hypermethylation frequencies of TIMP-3 and GSTP-1 of reversible chronic inflammatory gum disease and the control group were similar, but both were significantly lower than those for malignant disease patients (p<0.0001).