Angiosarcoma (AS) is a distinct group of sarcomas characterized by upregulation of vascular-specific receptor tyrosine kinases, including TIE1, KDR, TEK, and FLT1.
Angiosarcomas in <i>aP2-Cre;Dicer1<sup>Flox/-</sup></i> mice histologically and genetically resemble human angiosarcoma. miR-23 target genes, including the oncogenes <i>Ccnd1</i> as well as <i>Adam19, Plau</i>, and <i>Wsb1</i> that promote invasiveness and metastasis, were enriched in mouse and human angiosarcoma.
Prx II was strongly expressed in mature endothelial cells of benign vascular tumors, whereas it was expressed weakly or not expressed in immature endothelial cells in malignant tumors of Kaposi's sarcoma and angiosarcoma.
Prx II was strongly expressed in mature endothelial cells of benign vascular tumors, whereas it was expressed weakly or not expressed in immature endothelial cells in malignant tumors of Kaposi's sarcoma and angiosarcoma.
KIT positivity has been variably reported in sarcomas such as angiosarcoma, Ewing sarcoma, synovial sarcoma, leiomyosarcoma, and MFH; results of the last three are controversial.
ANX2 reactivity may be the basis of treatment for a variety of benign tumors, especially in pediatric patients, and may offer a new and potentially less toxic therapy for angiosarcoma.
CD31 immunostaining demonstrated that the human malignant vascular tumors Kaposi's sarcoma and angiosarcoma were filled with capillary-like structures, whereas in benign cavernous and capillary hemangiomas, blood vessels were not as abundantly present.
MET protein expression was observed in 2.6% of the cases, all of which were either undifferentiated pleomorphic sarcomas or angiosarcomas, showing positivity rates of 14% and 17%, respectively.