Multiple IFN response genes, particularly MX2 in naive B cells and CD163 in CD14<sup>+</sup> CD16<sup>+</sup> monocytes, were up-regulated in a cell-specific manner before progression to SD.
The IFN-α levels were found significantly higher in DF than DHF patients irrespective of the infecting serotype (DENV1 or 2), and were found to decline rapidly at day 3 after fever onset.