This chapter describes an assemblage of innovative NMR methods that have proved useful in detecting pathological cell dysfunctions in various preclinical models of HD.
To further explore the physiological processes linked to metabolite imbalances during HD, we have investigated the 1D <sup>1</sup>H NMR spectroscopy-based metabolomics profile of Drosophila HD model.
We have used (1)H NMR metabolome profiling to characterize metabolic aberrations in a yeast model of Huntington's disease that are attributable to the mutant huntingtin protein's gain-of-toxic-function effects.