Current literature on FLVCR2 is relatively sparse; identifying additional patients with similar mutations will aid in defining the clinical significance of a gene mutation and the contribution to the etiology of hydranencephaly.
These data demonstrate that HSPGs are important cellular attachment factors for AKAV and SBV, at least <i>in vitro</i>, to promote virus replication in susceptible cells.<b>IMPORTANCE</b> AKAV and SBV are the etiological agents of arthrogryposis-hydranencephaly syndrome in ruminants, which causes considerable economic losses in the livestock industry.
These data demonstrate that HSPGs are important cellular attachment factors for AKAV and SBV, at least <i>in vitro</i>, to promote virus replication in susceptible cells.<b>IMPORTANCE</b> AKAV and SBV are the etiological agents of arthrogryposis-hydranencephaly syndrome in ruminants, which causes considerable economic losses in the livestock industry.
Recently, longer expansion of the first polyalanine tract of ARX was found to be causative for Ohtahara syndrome without brain malformation, whereas premature termination mutations of ARX were found to cause severe brain malformations, such as lissencephaly or hydranencephaly.