Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5731
Gene Symbol: PTGER1
PTGER1 		0.300 Biomarker disease CTD_human The role of prostaglandin E2 receptor EP1 in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced neonatal hydronephrosis in mice. 30641090 2019
Entrez Id: 3418
Gene Symbol: IDH2
IDH2 		0.300 Biomarker disease CTD_human A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model. 27469509 2016
Entrez Id: 9536
Gene Symbol: PTGES
PTGES 		0.300 Biomarker disease CTD_human A mouse strain less responsive to dioxin-induced prostaglandin E2 synthesis is resistant to the onset of neonatal hydronephrosis. 25015655 2014
Entrez Id: 1958
Gene Symbol: EGR1
EGR1 		0.300 Biomarker disease CTD_human A mouse strain less responsive to dioxin-induced prostaglandin E2 synthesis is resistant to the onset of neonatal hydronephrosis. 25015655 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Biomarker disease CTD_human Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice. 22430074 2012
Entrez Id: 9536
Gene Symbol: PTGES
PTGES 		0.300 Biomarker disease CTD_human Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice. 22430074 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.210 AlteredExpression disease BEFREE TCDD-induced hydronephrosis was more severe in wild-type fetuses than in cPLA<sub>2</sub>α-null fetuses regardless of sex, and kidney expression levels of the inflammatory cytokines interleukin-1β and tumor necrosis factor-α were increased in a cPLA<sub>2</sub>α-dependent manner in TCDD-exposed fetuses. 29043426 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.210 Biomarker disease RGD Urine and kidney cytokine profiles in experimental unilateral acute and chronic hydronephrosis. 22150692 2012
Entrez Id: 6916
Gene Symbol: TBXAS1
TBXAS1 		0.200 Biomarker disease RGD Rat kidney thromboxane synthase: cDNA cloning and gene expression regulation in hydronephrotic kidney. 9261862 1997
Entrez Id: 2737
Gene Symbol: GLI3
GLI3 		0.130 AlteredExpression disease BEFREE Constitutive expression of GLI3 repressor in <i>Ptch1-</i>deficient mice rescued ectopic <i>Ptch2</i> expression and obstructive hydronephrosis. 29109083 2018
Entrez Id: 2737
Gene Symbol: GLI3
GLI3 		0.130 AlteredExpression disease BEFREE On the other hand, Gli3 repressor activity was enhanced, possibly contributing to hydronephrosis and impaired glomerulogenesis in some animals. 28615245 2017
Entrez Id: 2737
Gene Symbol: GLI3
GLI3 		0.130 Biomarker disease BEFREE Here, we review the pathobiology and clinical management of non-obstructive hydronephrosis and describe how inhibitors of GLI3 repressor formation may serve as novel therapies for this disorder. 23052658 2013
Entrez Id: 2737
Gene Symbol: GLI3
GLI3 		0.130 Biomarker disease HPO
Entrez Id: 6495
Gene Symbol: SIX1
SIX1 		0.120 Biomarker disease BEFREE Furthermore a lack of Six1 gene in the ureter leads to hydroureter and hydronephrosis. 24899122 2014
Entrez Id: 6495
Gene Symbol: SIX1
SIX1 		0.120 Biomarker disease BEFREE A lack of Six1 in the ureter led to hydroureter and hydronephrosis without anatomical obstruction when kidney formation was rescued in Six1(-/-) embryos by specifically expressing Six1 in the metanephric mesenchyme, but not the ureter, under control of the Eya1 promoter. 20110314 2010
Entrez Id: 6495
Gene Symbol: SIX1
SIX1 		0.120 Biomarker disease HPO
Entrez Id: 7474
Gene Symbol: WNT5A
WNT5A 		0.110 GeneticVariation disease BEFREE Hydronephrosis in the Wnt5a-ablated kidney is caused by an abnormal ureter-bladder connection. 27923152 2017
Entrez Id: 7020
Gene Symbol: TFAP2A
TFAP2A 		0.110 GeneticVariation disease BEFREE We report a 2-month-old boy with bilateral branchial cleft anomalies, low-set ears, and hydronephrosis who tested positive for a mutation in the TFAP2A gene (A256V) implicated in branchio-oculo-facial (BOF) syndrome. 22276601 2012
Entrez Id: 7474
Gene Symbol: WNT5A
WNT5A 		0.110 Biomarker disease HPO
Entrez Id: 7020
Gene Symbol: TFAP2A
TFAP2A 		0.110 Biomarker disease HPO
Entrez Id: 6899
Gene Symbol: TBX1
TBX1 		0.100 Biomarker disease HPO
Entrez Id: 55690
Gene Symbol: PACS1
PACS1 		0.100 CausalMutation disease CLINVAR
Entrez Id: 4774
Gene Symbol: NFIA
NFIA 		0.100 Biomarker disease HPO
Entrez Id: 7403
Gene Symbol: KDM6A
KDM6A 		0.100 Biomarker disease HPO
Entrez Id: 3981
Gene Symbol: LIG4
LIG4 		0.100 Biomarker disease HPO