Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN 		0.520 Therapeutic phenotype CTD_human Interleukin-1 receptor antagonist ameliorates neonatal lipopolysaccharide-induced long-lasting hyperalgesia in the adult rats. 20937348 2011
Entrez Id: 80036
Gene Symbol: TRPM3
TRPM3 		0.010 Biomarker phenotype BEFREE TRPM3-deficient mice exhibited clear deficits in their avoidance responses to noxious heat and in the development of inflammatory heat hyperalgesia. 21555074 2011
Entrez Id: 246213
Gene Symbol: SLC17A8
SLC17A8 		0.200 Biomarker phenotype RGD VGLUT3 is involved in conduction of visceral pain sensation and in visceral hyperalgesia induced by Trichinella spiralis infection in rats. 22160634 2012
Entrez Id: 1511
Gene Symbol: CTSG
CTSG 		0.010 Biomarker phenotype BEFREE CTSG blockade reduced heat hyperalgesia, accompanied by a reduction in neutrophil infiltration and interleukin 1β levels in the dorsal horns. 26270939 2015
Entrez Id: 3700
Gene Symbol: ITIH4
ITIH4 		0.050 Biomarker phenotype BEFREE Gp120 can directly stimulate the primary sensory afferent neurons and cause hyperalgesia. 28065732 2017
Entrez Id: 551
Gene Symbol: AVP
AVP 		0.310 Biomarker phenotype BEFREE Copeptin and cortisol were measured five times during an established model of transdermal electrical stimulation designed to assess pain and hyperalgesia. 28106611 2017
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.030 Biomarker phenotype BEFREE β-Endorphin plays an important role in the development of hyperalgesia. 28235500 2017
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B 		0.560 Biomarker phenotype BEFREE GluN2B antagonist also blocked CXCL13, and IL-17 directly induced hyperalgesia. 28359934 2017
Entrez Id: 57178
Gene Symbol: ZMIZ1
ZMIZ1 		0.010 Biomarker phenotype BEFREE ZMIZ1 has previously been associated with several autoimmune diseases, and NGF plays a key role in the generation of pain and hyperalgesia and has been associated with migraine. 28447608 2017
Entrez Id: 10068
Gene Symbol: IL18BP
IL18BP 		0.010 Biomarker phenotype BEFREE IL-18BP attenuated allodynia/hyperalgesia and IL-18 upregulation in the Vc. 28465227 2017
Entrez Id: 23476
Gene Symbol: BRD4
BRD4 		0.010 Biomarker phenotype BEFREE Bromodomain-containing protein 4 binds acetylated promoter histones and promotes transcription; however, the role of bromodomain-containing protein 4 in inflammatory hyperalgesia remains unclear. 28806224 2017
Entrez Id: 4803
Gene Symbol: NGF
NGF 		0.600 Biomarker phenotype BEFREE Nerve growth factor (NGF) injected into the human skin causes local hyperalgesia to mechanical and electrical stimuli lasting for weeks. 29140928 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.600 Biomarker phenotype BEFREE TRPV1 was responsible from the cisplatin-induced heat hyperalgesia and mechanical allodynia in the sensory neurons. 29326595 2017
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1 		0.400 Biomarker phenotype BEFREE Mu-opioid receptor (MOR) antisense prevented fentanyl hyperalgesia and priming. 29431655 2018
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B 		0.560 Biomarker phenotype BEFREE GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription. 29614314 2018
Entrez Id: 1392
Gene Symbol: CRH
CRH 		0.040 Biomarker phenotype BEFREE CRF mimicked the hyperalgesic response triggered by stress during latent sensitization, possibly by blocking inhibitory spinal descending signals that suppress hyperalgesia. 29776484 2018
Entrez Id: 10882
Gene Symbol: C1QL1
C1QL1 		0.020 Biomarker phenotype BEFREE CRF mimicked the hyperalgesic response triggered by stress during latent sensitization, possibly by blocking inhibitory spinal descending signals that suppress hyperalgesia. 29776484 2018
Entrez Id: 6223
Gene Symbol: RPS19
RPS19 		0.010 Biomarker phenotype BEFREE DBA/1 mice exhibited greater hyperalgesia and higher levels of inflammatory mediators. miR‑143‑3p expression in the blood and the dorsal root ganglion (DRG) were detected, and low miR‑143‑3p expression was demonstrated in the blood and DRG tissue of CIA mice. 30066874 2018
Entrez Id: 301
Gene Symbol: ANXA1
ANXA1 		0.210 Biomarker phenotype BEFREE Annexin 1 inhibits remifentanil-induced hyperalgesia and NMDA receptor phosphorylation via regulating spinal CXCL12/CXCR4 in rats. 30120960 2019
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1 		0.400 Biomarker phenotype BEFREE Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat. 30342200 2018
Entrez Id: 4803
Gene Symbol: NGF
NGF 		0.600 Biomarker phenotype BEFREE Nerve growth factor is an inflammatory mediator that induces long-lasting hyperalgesia, which can partially be attributed to nerve growth factor-induced sensitization of primary afferent nociceptors. 30387376 2019
Entrez Id: 11126
Gene Symbol: CD160
CD160 		0.020 Biomarker phenotype BEFREE NK1 receptor is involved in nociception, but our earlier data showed that it has no role in chronic neuropathic hyperalgesia, similarly to SP. 30664920 2019
Entrez Id: 27087
Gene Symbol: B3GAT1
B3GAT1 		0.020 Biomarker phenotype BEFREE NK1 receptor is involved in nociception, but our earlier data showed that it has no role in chronic neuropathic hyperalgesia, similarly to SP. 30664920 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.580 Biomarker phenotype BEFREE Interleukin-6 Inhibitor Suppresses Hyperalgesia Without Improvement in Osteoporosis in a Mouse Pain Model of Osteoporosis. 30666355 2019
Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14 		0.030 Biomarker phenotype BEFREE p38 mitogen-activated protein kinase (p38 MAPK) activation involves the release of prostaglandin E2 (PGE2) and hyperalgesia. 30977668 2019