Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 22933
Gene Symbol: SIRT2
SIRT2
0.200 Biomarker phenotype RGD Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. 23658678 2013
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.200 Biomarker phenotype RGD Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. 23658678 2013
Entrez Id: 581
Gene Symbol: BAX
BAX
0.200 Biomarker phenotype RGD Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. 23658678 2013
Entrez Id: 572
Gene Symbol: BAD
BAD
0.200 Biomarker phenotype RGD Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. 23658678 2013
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.200 Therapeutic phenotype RGD Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. 23658678 2013
Entrez Id: 578
Gene Symbol: BAK1
BAK1
0.200 Biomarker phenotype RGD Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. 23658678 2013
Entrez Id: 27113
Gene Symbol: BBC3
BBC3
0.200 Biomarker phenotype RGD Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. 23658678 2013
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
0.200 Therapeutic phenotype RGD Silencing of int6 gene restores function of the ischaemic hindlimb in a rat model of peripheral arterial disease. 21771896 2011
Entrez Id: 3646
Gene Symbol: EIF3E
EIF3E
0.200 Therapeutic phenotype RGD Next, we explored the therapeutic effects of int6 siRNA injected into the adductor magnus muscle on IC. 21771896 2011
Entrez Id: 4000
Gene Symbol: LMNA
LMNA
0.100 Biomarker phenotype HPO
Entrez Id: 10269
Gene Symbol: ZMPSTE24
ZMPSTE24
0.100 Biomarker phenotype HPO
Entrez Id: 64131
Gene Symbol: XYLT1
XYLT1
0.100 Biomarker phenotype HPO
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.100 GeneticVariation phenotype CLINVAR
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.100 CausalMutation phenotype CLINVAR
Entrez Id: 64132
Gene Symbol: XYLT2
XYLT2
0.100 Biomarker phenotype HPO
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker phenotype HPO
Entrez Id: 189
Gene Symbol: AGXT
AGXT
0.100 Biomarker phenotype HPO
Entrez Id: 4352
Gene Symbol: MPL
MPL
0.100 Biomarker phenotype HPO
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.100 Biomarker phenotype HPO
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.100 Biomarker phenotype HPO
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.030 AlteredExpression phenotype BEFREE Plasma concentrations of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), interleukin-1ß (IL-1ß), hepatocyte growth factor, and vascular endothelial growth factor were higher in IC subjects at baseline, and TNF-α, IL-6, and IL-18 increased after walking as did IL-6 and IL-1ß in control subjects. 30684623 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.030 Biomarker phenotype BEFREE In this study we examined the effects of VEGF GT on patients having received VEGF-A gene transfer for the treatment of symptomatic (that is, claudication or critical lower limb ischemia) peripheral arterial occlusive disease. 21776026 2012
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.030 Biomarker phenotype BEFREE Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. 14504183 2003
Entrez Id: 23569
Gene Symbol: PADI4
PADI4
0.020 Biomarker phenotype BEFREE Methods and Results A total of 1272 patients with PAD and new or worsening claudication were enrolled at 16 vascular specialty clinics (2011-2015, PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) registry). 30371269 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.020 Biomarker phenotype BEFREE Presence of temporal headache (p = 0.003), jaw claudication (p = 0.001), abnormal artery exploration (p = 0.023), elevated erythrocyte sedimentation rate (p = 0.035), CRP (p = 0.018) and platelets (p = 0.042), were significantly associated with GCA. 29680850 2018