×
Entrez Id: 9445
Gene Symbol: ITM2B
ITM2B
0.010
Biomarker
disease
BEFREE
Besides, the updated criteria also had great impacts on clinical parameters, sleep quality and psychological state of IBS patients.HighlightsRome IV criteria removed the description of abdominal discomfort for IBS .The updated Rome criteria had great impacts on IBS patients in our database.Our study analyzed the characteristics of IBS patients who fulfilled both criteria.Alterations in the Rome criteria also led to changes in the disease spectrum of FBD .
31829752 2019
×
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
0.010
Biomarker
disease
BEFREE
We investigated the role of vagal transient receptor potential ankyrin 1 (TRPA1 , a cold-sensing ion channel) in cold-aggravated visceral mechanonociception in a stress-induced IBS animal model.
31327223 2019
×
Entrez Id: 84868
Gene Symbol: HAVCR2
HAVCR2
0.010
Biomarker
disease
BEFREE
The expression of CD11C+CD80+ and CD11c+TIM3 + in intestinal LPDCs in mice with IBS increased significantly.
31576093 2019
×
Entrez Id: 6754
Gene Symbol: SSTR4
SSTR4
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor ; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
31272268 2019
×
Entrez Id: 10663
Gene Symbol: CXCR6
CXCR6
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor ; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
31272268 2019
×
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR : G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
31272268 2019
×
Entrez Id: 7037
Gene Symbol: TFRC
TFRC
0.010
Biomarker
disease
BEFREE
Reduced frequency and/or impaired functionality of CD71 + erythroid cells during pregnancy may predispose IBD patients to a more pro-inflammatory milieu in their gastrointestinal tract, characterised by lower Tregs, higher IL-6, and TNF-α, and dysbiosis.
30272151 2019
×
Entrez Id: 1081
Gene Symbol: CGA
CGA
0.010
GeneticVariation
disease
BEFREE
Components of a CGA were associated with adverse health outcomes in IBD patients, but older patients were under-represented.
31002331 2019
×
Entrez Id: 146059
Gene Symbol: CDAN1
CDAN1
0.010
Biomarker
disease
BEFREE
We found female gender as well as a longer disease duration and activity (specified as CDAI or MTWAI, respectively) to be related to the appearance of arthritis/arthralgia, but also sacroiliitis/ankylosing spondylitis in IBD patients.
31039159 2019
×
Entrez Id: 60674
Gene Symbol: GAS5
GAS5
0.010
Biomarker
disease
BEFREE
Long Non-Coding RNA GAS5 and Intestinal MMP2 and MMP9 Expression: A Translational Study in Pediatric Patients with IBD .
31652976 2019
×
Entrez Id: 286
Gene Symbol: ANK1
ANK1
0.010
Biomarker
disease
BEFREE
NEW & NOTEWORTHY We provide evidence for histamine-mediated transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 sensitization in irritable bowel syndrome (IBS ) via histamine 1 receptor (H<sub>1</sub>R) activation, most likely contributing to increased visceral pain perception.
30629470 2019
×
Entrez Id: 134391
Gene Symbol: GPR151
GPR151
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR : G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
31272268 2019
×
Entrez Id: 799
Gene Symbol: CALCR
CALCR
0.010
GeneticVariation
disease
BEFREE
We investigated the intestinal mucosa and the mesenteric adipose tissue (MAT) collected from CD patients with active disease (CD group) and from non-IBD patients (CTR group) to study ER stress activation and to address tissue-specific modulation in CD.
31557250 2019
×
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.010
Biomarker
disease
BEFREE
These findings underline the crucial regulatory role of IL-23 in chronic intestinal inflammation and colitis-associated cancer and indicate that therapeutic strategies aiming at IL-23 blockade may be of key relevance for future therapy of IBD patients.
30563755 2019
×
Entrez Id: 214
Gene Symbol: ALCAM
ALCAM
0.010
Biomarker
disease
BEFREE
Expression of CD6 and its ligand ALCAM was markedly increased in the inflamed mucosa of IBD patients compared with that in normal controls, and was significantly correlated with disease activity indices of IBD patients.
30395204 2019
×
Entrez Id: 222545
Gene Symbol: GPRC6A
GPRC6A
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR : G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
31272268 2019
×
Entrez Id: 1756
Gene Symbol: DMD
DMD
0.010
Biomarker
disease
BEFREE
Abbreviations: AGA: anti-gliadin antibodies; Anti-DGP-ab: anti-deamidated gliadin peptide antibodies; Anti-tTG-ab: anti-tissue transglutaminase antibodies; ATD: auto-immune thyroid disorders; BMD : bone mineral density; CD: coeliac disease; DH: dermatitis herpetiformis; EMA: anti-endomysial antibodies; FDR: first-degree relatives; GFD: gluten-free diet; HbA1c: haemoglobin A1c; HLA: human leucocyte antigen; IBS: irritable bowel syndrome ; LMIC: low- and middle-income countries; NPV: negative predictive value; NRCD: non-responsive coeliac disease; POCT: point-of-care tests; SDR: second-degree relatives; SIBO: small intestinal bacterial overgrowth; T1DM: type 1 diabetes mellitus; ULN: upper limit of normal.
30099930 2019
×
Entrez Id: 2866
Gene Symbol: GPR42
GPR42
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor ; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
31272268 2019
×
Entrez Id: 117195
Gene Symbol: MRGPRX3
MRGPRX3
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR : G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
31272268 2019
×
Entrez Id: 55000
Gene Symbol: TUG1
TUG1
0.010
Biomarker
disease
BEFREE
This study aimed to explore the effects of long non-coding RNA taurine upregulated gene 1 (TUG1 ) on tumor necrosis factor alpha (TNF-α)-induced interstitial cells of Cajal (ICC) inflammatory injury, which was relevant to the pathogenesis of IBS .
30657572 2019
×
Entrez Id: 8997
Gene Symbol: KALRN
KALRN
0.010
Biomarker
disease
BEFREE
In network meta-analysis, the protocol of DUO had a significant effect for diarrhea type of IBS compared with placebo (RR: 7.46; 95% CI: 2.00-32.23).
31277101 2019
×
Entrez Id: 2806
Gene Symbol: GOT2
GOT2
0.010
AlteredExpression
disease
BEFREE
Intestinal fatty acid binding protein levels in irritable bowel syndrome patients were not increased suggesting no significant increase in enterocyte death.
31210949 2019
×
Entrez Id: 680
Gene Symbol: BRS3
BRS3
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor ; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
31272268 2019
×
Entrez Id: 2917
Gene Symbol: GRM7
GRM7
0.010
Biomarker
disease
BEFREE
Therefore, the present study aimed to evaluate the possible effects of mGluR7 on the visceral hypersensitivity of irritable bowel syndrome (IBS ) in rats.
30569115 2019
×
Entrez Id: 4041
Gene Symbol: LRP5
LRP5
0.010
GeneticVariation
disease
BEFREE
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5 /6: low-density lipoprotein receptor-related protein 5 /6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
31272268 2019