Gene: FLT3 ×
Source: INFERRED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 Biomarker disease HPO
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608 2001
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells. 14604974 2004
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia. 14737077 2004
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420 2004
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant. 16091740 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3. 15667533 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. 15374878 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia. 15625552 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia. 15863200 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR The other novel mutation, FLT3 K663Q, is the first AML-associated gain-of-function mutation located outside the JM and AL domains. 16990784 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations. 16573742 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML. 16410449 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Novel observation of three FLT3 codons mutated in tandem in an elderly acute myeloid leukaemia patient. 16371029 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways. 17047150 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen. 17606455 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations. 17889720 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Recurring mutations found by sequencing an acute myeloid leukemia genome. 19657110 2009
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR [FMS-like tyrosine kinase 3 gene mutations in acute myeloid leukemia]. 19840437 2009
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. 20733134 2010
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. 22504183 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR MicroRNAs in liver disease. 22504185 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184 2012