Gene: FLT3 ×
Source: INFERRED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia. 23878140 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. 23321257 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia. 23783394 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Mutational landscape of AML with normal cytogenetics: biological and clinical implications. 23261068 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. 23714533 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia. 24046014 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. 22504183 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR MicroRNAs in liver disease. 22504185 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Continuing aspirin in the perioperative patient. 22504186 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. 20733134 2010
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Recurring mutations found by sequencing an acute myeloid leukemia genome. 19657110 2009
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR [FMS-like tyrosine kinase 3 gene mutations in acute myeloid leukemia]. 19840437 2009
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways. 17047150 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen. 17606455 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations. 17889720 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR The other novel mutation, FLT3 K663Q, is the first AML-associated gain-of-function mutation located outside the JM and AL domains. 16990784 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations. 16573742 2006