|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
In order to find potential correlations between HLA class II alleles and anti-SS-A, -SS-B, -Sm and anti-snRNP responses among Norwegian patients with systemic lupus erythematosus (SLE), HLA-DRB1, -DRB3*0101, -DQA1 and -DQB1 alleles were determined by DNA typing 50 patients and 108 controls.
|
7481563 |
1995 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls).
|
26605347 |
2015 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
In conclusion, our observations showed that HLA-G 14bp ins allele represents a genetic contribution on early-onset SLE independent of DRB1.
|
27331404 |
2016 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A total of 25 case-control studies on the relationship between gene polymorphism of HLA-DRB l and SLE were performed and data were analyzed and processed using Review Manager 5.2 and Stata 11.0.
|
25546242 |
2015 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB genes and antiribosomal P antibodies in systemic lupus erythematosus.
|
8000739 |
1994 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes.
|
23407388 |
2013 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Classic HLA allele imputation analysis identified HLA-DRB1*1501 and HLA-DQB1*0602, each highly correlated with one another, as most strongly associated with SLE.
|
26663301 |
2016 |
|
HLA-DRB1
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
The most strongly associated SNP with SLE was the rs9271366 (odds ratio, OR = 1.70, p = 5.6 × 10(-5)) near the HLA-DRB1 gene.
|
21695597 |
2011 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No correlation was found between TNF promoter and HLA-DRB1 genotypes and any SLE classification criterion or disease manifestation.
|
10643708 |
2000 |
|
HLA-DRB1
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Our data suggest an association between MHC class I and class II (HLA-A*29, HLA-B*51, HLA-DRB1*15, and HLA-DQB1*06) and susceptibility to SLE in the Saudi population.
|
23793423 |
2014 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*08 was associated with SLE among the Hispano-Americans but not among the Spaniards.
|
12765301 |
2003 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The 7 SNPs and 4 HLA-DRB1 alleles associated with SLE did not display strong associations with ANA positivity.
|
25186300 |
2014 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although no HLA-DRB1 allele was found to be significantly associated with SLE, the associations with DQB1*0501 and TNF2 suggest that DQB1 and tumor necrosis factor a may be important genetic factors in SLE susceptibility in the Chinese population in Taiwan.
|
9182925 |
1997 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the Taq I digested DNA restriction fragment length polymorphism (RFLP) of the Major Histocompatibility Complex (MHC) class II genes: HLA-DRB, -DQA, and the class III genes: C4 and 21-hydroxylase(CYP21) in 56 caucasoid patients with systemic lupus erythematosus (SLE) and 62 control subjects in order to define the molecular variation of these genes and their association with SLE.
|
1973860 |
1990 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
LHGDN |
Associations of erosive arthritis with anti-cyclic citrullinated peptide antibodies and MHC Class II alleles in systemic lupus erythematosus.
|
18085741 |
2008 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This may suggest that HLA class II molecules themselves and/or an unknown susceptibility gene located near the DQA1 and DRB1 loci are involved in the pathogenesis of SLE.
|
7481564 |
1995 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 gene is a mayor factor for development of SLE in Latin Americans.
|
18295738 |
2008 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE.
|
26919467 |
2016 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that CTLA-4 exon 1 polymorphism does not contribute greatly to the susceptibility to RA and SLE, at least in Japanese, although the presence of CTLA4 49G allele could be a minor predisposing factor for RA in HLA-DRB1*0405-positive individuals.
|
10674972 |
1999 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results confirm the association between TNF and DRB1 polymorphisms and SLE.
|
29912900 |
2018 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We detected 6 HLA-DRB1 alleles that were associated with SLE in Koreans.
|
26663868 |
2016 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
The combinations DRB1*0301-MICA5.1-B8 and HLA-DRB1*0301-B*08-positive and MICA5-1-negative were more frequent among SLE patients (11.4 vs 3.3% in healthy controls, P = 3.9 x 10(-5), OR 3.76, 95% CI 1.85-7.73, and 6.9 vs 1.7%, P = 0.0007, OR 4.32, 95% CI 1.68-13.10, respectively).
|
16537577 |
2006 |
|
HLA-DRB1
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
19838195 |
2009 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
The association of 196R allele with SLE was independent from that of HLA-DRB1*1501.
|
10395102 |
1999 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study demonstrated that the presence of HLA-DRB1*15 was a strong factor that predisposed patients to the development of SLE and LN, but did not influence kidney graft survival.
|
29421495 |
2018 |