|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
When compared to the low-risk group (nonDRB1*03 class II heterozygotes), the cases homozygous for DRB1*03,DQA1*0501,DQB1*0201, known to be in linkage disequilibrium with the complement allele C4A*Q0, had the highest relative risk of developing SLE (RR = 16.39, p = 0.0002).
|
1440567 |
1992 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the Taq I digested DNA restriction fragment length polymorphism (RFLP) of the Major Histocompatibility Complex (MHC) class II genes: HLA-DRB, -DQA, and the class III genes: C4 and 21-hydroxylase(CYP21) in 56 caucasoid patients with systemic lupus erythematosus (SLE) and 62 control subjects in order to define the molecular variation of these genes and their association with SLE.
|
1973860 |
1990 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
In order to find potential correlations between HLA class II alleles and anti-SS-A, -SS-B, -Sm and anti-snRNP responses among Norwegian patients with systemic lupus erythematosus (SLE), HLA-DRB1, -DRB3*0101, -DQA1 and -DQB1 alleles were determined by DNA typing 50 patients and 108 controls.
|
7481563 |
1995 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This may suggest that HLA class II molecules themselves and/or an unknown susceptibility gene located near the DQA1 and DRB1 loci are involved in the pathogenesis of SLE.
|
7481564 |
1995 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*03 was less strongly linked to DQB1*02 in this population than in white populations and was not associated with SLE.
|
7677446 |
1995 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*0301 and C4A*Q0 were each increased in the SLE patients, especially HLA-DRB1*0301 in those with anti-Ro/SSA autoantibodies.
|
7792766 |
1995 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To investigate a possible involvement of HLA-class II alleles in the genetic predisposition for the formation of anti-U1-nRNP antibody-in systemic lupus erythematosus (SLE), genomic DNA of 178 patients was typed for the DRB1, DQA1 and DQB1 alleles using a polymerase chain reaction (PCR) and non-radioactive-oligonucleotide typing.
|
7824837 |
1994 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our data suggested that the presence of C4AQ0 allele, DRB1*1501-DRB5*0101 haplotype and DR9 contributed to susceptibility to SLE in Koreans and that Korean SLE is based on a different genetic background from Caucasian patients.
|
7911834 |
1994 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the DNA restriction fragment length polymorphism (RFLP) of the major histocompatibility complex (MHC) genes: HLA-DRB, -DQA, -DQB, -DPB in 24 Danish patients with systemic lupus erythematosus (SLE) and in 102 healthy Danes.
|
7912858 |
1994 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB genes and antiribosomal P antibodies in systemic lupus erythematosus.
|
8000739 |
1994 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The strongest association to SLE is found with DRB1*03 and DOB1*0201 alleles (p < 10(-7), p corr.< 10(-5) and p < 10(-6), p corr.< 10(-4), respectively).
|
8406614 |
1993 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*0301, DQA1*0501, DQB1*0201 was more common in Caucasians and DRB1*1503, DRB5*0101, DQA1*0102, DQB1*0602 in American blacks, regardless of age at SLE onset.
|
8452580 |
1993 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The typing results suggest that susceptibility to MCTD is strongly associated with the HLA-DRB1*0401-DRB4*0101-DQA1*03-DQB1*0301 haplotype, and that to SLE is associated with the HLA-DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602 haplotype.
|
8456439 |
1993 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
Furthermore, these was no evidence for linkage disequilibrium between any TAP1/TAP2 alleles and HLA-DRB1*1501--which is reported to be weakly but significantly association with Japanese SLE--in either the normal control or the SLE patient group.
|
9014588 |
1996 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
There was no significantly different distribution of HLA-DRB1 alleles between SLE patients with nephritis and without nephritis.
|
9157084 |
1996 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although no HLA-DRB1 allele was found to be significantly associated with SLE, the associations with DQB1*0501 and TNF2 suggest that DQB1 and tumor necrosis factor a may be important genetic factors in SLE susceptibility in the Chinese population in Taiwan.
|
9182925 |
1997 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This suggests the possibility of extended haplotypes encoding for HLA-DRB1 susceptibility and high prolactin production, which contribute to susceptibility to both RA and SLE.
|
9259416 |
1997 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
A possible association of DRB1*0901 with Japanese SLE patients with beta 2 GPI-dependent aCL was found.
|
9706422 |
1998 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
The association of 196R allele with SLE was independent from that of HLA-DRB1*1501.
|
10395102 |
1999 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No correlation was found between TNF promoter and HLA-DRB1 genotypes and any SLE classification criterion or disease manifestation.
|
10643708 |
2000 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that CTLA-4 exon 1 polymorphism does not contribute greatly to the susceptibility to RA and SLE, at least in Japanese, although the presence of CTLA4 49G allele could be a minor predisposing factor for RA in HLA-DRB1*0405-positive individuals.
|
10674972 |
1999 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
CTD_human |
HLA-DRB1*0301 and DQA1*0501 in RA.
|
11436868 |
2001 |
|
HLA-DRB1
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Finally, the low frequency of the DRB1*0301 and DRB1*1501 alleles in the control population suggests that the genetic admixture between Mexican Indians and Caucasian populations was an event that could have increased the risk of Mexicans to develop SLE.
|
11476905 |
2001 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings confirmed the association of HLA-DRB1*1501, but did not replicate that of the HLA-DRB1*0301, TNFA-308A and TNFR2-196R with SLE in this population.
|
11607787 |
2001 |
|
HLA-DRB1
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated whether the association of HLA-DRB1*0301 (HLA-DR3) and TNF-308A with SLE could be attributed to polymorphic markers in the chromosomal region encompassed by HLA-DRB1 and HLA-C. Ninety-one consecutive Caucasian patients with SLE and 253 controls (organ donors) were typed for HLA-DRB1, microsatellites D6S1014, D6S273, TNFa, MIB, C1_2_5, and C1_3_2 and the single nucleotide polymorphism at position -308 in the promoter of TNF.
|
11704803 |
2001 |