Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.210 Biomarker phenotype BEFREE Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration. 14605247 2004
Entrez Id: 183
Gene Symbol: AGT
AGT
0.210 Biomarker phenotype RGD Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration. 14605247 2004
Entrez Id: 1386
Gene Symbol: ATF2
ATF2
0.210 GeneticVariation phenotype BEFREE Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome. 10364225 1999
Entrez Id: 1386
Gene Symbol: ATF2
ATF2
0.210 Biomarker phenotype MGD
Entrez Id: 186
Gene Symbol: AGTR2
AGTR2
0.200 Therapeutic phenotype RGD Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration. 14605247 2004
Entrez Id: 100505887
Gene Symbol: LINC01672
LINC01672
0.020 Biomarker phenotype BEFREE Quantifying proton NMR coherent linewidth in proteins under fast MAS conditions: a second moment approach. 31432055 2019
Entrez Id: 10133
Gene Symbol: OPTN
OPTN
0.020 Biomarker phenotype BEFREE The recent NRP guideline change was not associated with an increased incidence of meconium aspiration syndrome but was associated with an increased incidence of NICU admissions for respiratory issues. 30385640 2018
Entrez Id: 4673
Gene Symbol: NAP1L1
NAP1L1
0.020 Biomarker phenotype BEFREE The recent NRP guideline change was not associated with an increased incidence of meconium aspiration syndrome but was associated with an increased incidence of NICU admissions for respiratory issues. 30385640 2018
Entrez Id: 100505887
Gene Symbol: LINC01672
LINC01672
0.020 Biomarker phenotype BEFREE In this tutorial review, we provide an overview of the most robust and efficient NMR experiments for half-integer quadrupolar nuclei, from simple one-dimensional acquisition under static and MAS conditions up to high-resolution and heteronuclear correlation two-dimensional spectra, as illustrated by selected examples. 29610785 2018
Entrez Id: 8829
Gene Symbol: NRP1
NRP1
0.020 Biomarker phenotype BEFREE The recent NRP guideline change was not associated with an increased incidence of meconium aspiration syndrome but was associated with an increased incidence of NICU admissions for respiratory issues. 30385640 2018
Entrez Id: 10133
Gene Symbol: OPTN
OPTN
0.020 Biomarker phenotype BEFREE ET: endotracheal; ILCOR: International Liaison Committee on Resuscitation; HIE: hypoxic ischaemic encephalopathy; LMIC: low- and middle-income countries; MAS: meconium aspiration syndrome; MSAF: meconium-stained amniotic fluid; NRP: neonatal resuscitation programme; PPHN: persistent pulmonary hypertension of the newborn; RCT: randomised controlled trial. 30160618 2018
Entrez Id: 4673
Gene Symbol: NAP1L1
NAP1L1
0.020 Biomarker phenotype BEFREE ET: endotracheal; ILCOR: International Liaison Committee on Resuscitation; HIE: hypoxic ischaemic encephalopathy; LMIC: low- and middle-income countries; MAS: meconium aspiration syndrome; MSAF: meconium-stained amniotic fluid; NRP: neonatal resuscitation programme; PPHN: persistent pulmonary hypertension of the newborn; RCT: randomised controlled trial. 30160618 2018
Entrez Id: 8829
Gene Symbol: NRP1
NRP1
0.020 Biomarker phenotype BEFREE ET: endotracheal; ILCOR: International Liaison Committee on Resuscitation; HIE: hypoxic ischaemic encephalopathy; LMIC: low- and middle-income countries; MAS: meconium aspiration syndrome; MSAF: meconium-stained amniotic fluid; NRP: neonatal resuscitation programme; PPHN: persistent pulmonary hypertension of the newborn; RCT: randomised controlled trial. 30160618 2018
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.020 GeneticVariation phenotype BEFREE MAS is caused by an activating mutation of the GNAS gene which leads to increased cyclic (c) adenosine monophosphate (AMP) signaling. 26188235 2016
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.020 GeneticVariation phenotype BEFREE MAS is due to activating mutations of GNAS, the gene encoding Gsalpha. 17982386 2007
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.020 AlteredExpression phenotype BEFREE Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs. 12621123 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.020 AlteredExpression phenotype BEFREE Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs. 12621123 2003
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.020 AlteredExpression phenotype BEFREE In vitro steroids down-regulated the iNOS expression, thus suggesting a potential to down-regulate NO-mediated inflammation in neonates with meconium aspiration syndrome. 11385144 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.020 AlteredExpression phenotype BEFREE Our data thus indicate that meconium aspiration induces pulmonary expression of cyclooxygenase-2, suggesting an important role for prostaglandins in the meconium aspiration-induced inflammation in neonatal lungs. 10328330 1999
Entrez Id: 4907
Gene Symbol: NT5E
NT5E
0.010 Biomarker phenotype BEFREE SAS vs. MAS patients were noted to have significantly higher percentage of CD73+ EM Tcyt (<i>p</i> = 0.006) and CD73+ CM Tcyt (<i>p</i> = 0.002). 31402927 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.010 Biomarker phenotype BEFREE Degradation of Lung Protective Angiotensin Converting Enzyme-2 by Meconium in Human Alveolar Epithelial Cells: A Potential Pathogenic Mechanism in Meconium Aspiration Syndrome. 30759273 2019
Entrez Id: 174
Gene Symbol: AFP
AFP
0.010 Biomarker phenotype BEFREE MAS should be considered part of the differential diagnosis of neonatal cholestasis and affected children should be closely monitored for the development of hepatic lesions with regular liver ultrasound and alpha fetoprotein level. 30628989 2019
Entrez Id: 727
Gene Symbol: C5
C5
0.010 Biomarker phenotype BEFREE To assess the efficacy of the combined inhibition of complement (C5) and CD14 on systemic inflammation induced in a forceful piglet MAS model. 29486477 2018
Entrez Id: 277
Gene Symbol: AMY1B
AMY1B
0.010 AlteredExpression phenotype BEFREE Concerning sAA, MDD patients had higher sAA levels upon awakening on two consecutive days (p = 0.04, p = 0.01 respectively), as well as a higher area under the curve with respect to the increase (AUCi; p = 0.04) in comparison to both controls and the other MAS-disorders group. 30005283 2018
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
0.010 AlteredExpression phenotype BEFREE The present study evaluated the expression of TLR 1, 4, 7, 8 and 9 in neonates with MAS. 29095429 2018