Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE Novel PPARα agonists, PPARδ agonists, PPARγ agonists, PPARα/γ dual agonists, and PPARγ antagonists have been claimed for the treatment of metabolic disease and inflammatory disease. 31825687 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker group BEFREE The protective effect of respondent education remained persistent for CRP but declined with age for metabolic disorder. 30252104 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker group BEFREE The role of C-reactive protein after surgery for obesity and metabolic disorders. 31784329 2020
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE Hepatic Interferon Regulatory Factor 6 Alleviates Liver Steatosis and Metabolic Disorder by Transcriptionally Suppressing Peroxisome Proliferator-Activated Receptor γ in Mice. 30748020 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE PPARγ is a pharmacological target in inflammatory and metabolic diseases. 31534496 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE These data highlight human genetic variation that impacts PPARγ genomic occupancy and patient responses to antidiabetic drugs, with implications for developing personalized therapies for metabolic disorders. 30639037 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE Mice deficient in mitochondrial promoter peroxisome proliferator activated receptor-γ co-activator-1β (<i>Pgc-1β<sup>-/-</sup></i> ) is a valuable model for metabolic diseases and has been found to present with several pathologies including ventricular arrhythmia. 30914453 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE Our findings establish a critical role of AhR in regulating PPARγ stability and suggest that the AhR-PPARγ interaction may represent a potential therapeutic target for managing metabolic diseases arising from PPARγ dysfunction. 31653699 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 AlteredExpression group BEFREE Therefore, PRMT6 may serve as an important regulator of PPARγ activity in adipogenic differentiation and may be an attractive therapeutic target for human metabolic diseases. 30942395 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker group BEFREE If defined as CRP>3 mg/L, the prevalence of low-grade inflammation among BD was 10.1% (41/404), it was positively associated with BMI (p = 0.012), comorbidity of glycolipid metabolic diseases(p = 0.018). 30597323 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 AlteredExpression group BEFREE In summary, the study suggests that COS can improve glucolipid metabolism disorder by suppressing inflammation and upregulating PPARγ expression. 30463189 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE The identification of the GHRP-CD36-PPARγ pathway in controlling various tissue metabolic functions provides an interesting option for metabolic disorders. 29883404 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE Taken together, these data indicate that TRIM25 is a novel E3 ubiquitin ligase of PPARγ and that TRIM25 is a novel target for PPARγ-associated metabolic diseases. 30323259 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE Strategies to leverage PPARγ deacetylation may lead to the design of safer, more effective agonists of this nuclear receptor in the treatment of metabolic diseases. 29589839 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE Aloxe3 is, therefore, a potentially novel effector of the hepatocellular fasting response that leverages both PPARγ-mediated and pleiotropic effects to augment hepatic and whole-host metabolism, and it is, thus, a promising target to ameliorate metabolic disease. 30135298 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression group BEFREE Within the patient cohort GDF15 levels were evaluated for association with age, gender, lifestyle factors, C-reactive protein levels, psychosis severity and metabolic disorder. 28801589 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE PPARγ (Peroxisome proliferator-activated receptor γ) is a nuclear receptor involved in lipid homeostasis and related metabolic diseases. 28059128 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation group BEFREE Elevated levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular and metabolic disease. 27977503 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency. 26775807 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 AlteredExpression group BEFREE Peroxisome proliferator-activated receptor gamma (PPAR-γ), a ligand-activated transcription factor has been investigated as the target for cancer treatment as well as metabolic disorders. 25931782 2015
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression group BEFREE We believe CRP variability likely reflects poor control of or greater changes in vascular or metabolic disease over time, which in turn is associated with cognitive decline. 24997674 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE These results revealed an alternative mechanism for PPARγ regulation and provided a potential target for the treatment of cholesterol metabolic diseases. 24751522 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE Role of PPARγ has been well established in variety of metabolic disorders and in regulation of inflammation. 23633103 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 GeneticVariation group BEFREE The peroxisome proliferator-activated receptor gamma 2 (PPARG2) gene has been intensively studied with relation to obesity and metabolic disorders. 23666678 2013
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker group BEFREE These results show that selective PPARγ-activation by diet-derived ligands may constitute a promising approach to combat metabolic disease. 22509006 2012