|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multiple sclerosis (MS) has, since the 1970s, been known to be associated with the HLA-Dw2 and -DR2 specificities in Caucasian Europeans and North Americans.
|
1926129 |
1991 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the candidate genes for multiple sclerosis (MS), the strongest influence is conferred by human leucocyte antigen (HLA) class II genes, in particular the DR2, DQ6, Dw2 haplotype (DRB1*1501, DQA1*0102, DQB1*0602).
|
11082515 |
2000 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely to the well-established association of DR2/Dw2 with multiple sclerosis (MS) susceptibility in Caucasoids, several studies have found an association of DR4 in populations from Mediterranean origin.
|
2033119 |
1991 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extensive analysis of restriction fragment length polymorphism using HLA class II and T-cell receptor gene probes has been carried out in an attempt to identify genetic markers more strongly associated with multiple sclerosis than the classically defined antigens DR2, Dw2, and DQw1.
|
2567726 |
1989 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DR15 haplotypes, including genomic variants of HLA-DRB5, and HLA-DR4 haplotypes affect MS risk.
|
29683085 |
2019 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, using a sibling pair linkage analysis that restricts haplotype sharing probabilities to defined genetic models, we have not observed linkage of this region to susceptibility in MS. We discuss the basis for association and linkage and conclude that the DR15, DQ6, Dw2 haplotype does represent a susceptibility locus but its contribution to the pathogenesis is small; although it may interact epistatically with other susceptibility genes, this haplotype is not necessary for disease expression.
|
7759607 |
1995 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we observed significant transmission distortion and an intrafamilial association of the MS-associated class II haplotype HLA-Dw2.
|
9065561 |
1997 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
In Black American MS patients, the B7 frequency is slightly increased but Dw2 is still significantly associated with MS. For the HLA-DR antigen series DR2 is shown to have a stronger association to MS than A3 and B7.
|
6953617 |
1982 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In fact, analysis of 19 patients homozygous for the MS associated HLA-DR-DQ haplotype HLA-Dw2 showed that this haplotype does not carry the TNF2 allele.
|
8550811 |
1995 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple sclerosis (MS)-associated haplotype HLA-DR15 Dw2, in presenting myelin basic protein (MBP) peptides to MBP-specific T cell lines (TCL).
|
9258250 |
1997 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Linkage of a hypothesized multiple sclerosis susceptibility gene with certain haplotypes of HLA-A3, HLA-B7 HLA-DW2, and the new B group 4 can be inferred.
|
1085490 |
1976 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
Normal or only slightly elevated frequencies of B7 and Dw2 were found in MS patients without oligoclonal CSF IgG (35 and 29%), normal CSF-IgG index (43 and 39%), and the most benign course (42 and 37%).
|
90443 |
1979 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
ON differs from both MS and controls regarding HLA-Dw2.
|
8899048 |
1996 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results on serotyping for "B-cell DW2" antigen are suggestive of an increased frequency of this antigen in chronic progressive MS patients (RR = 2.9, P = 0.01).
|
71339 |
1977 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
Surprisingly, these changes which favour a beneficial, disease-downregulating effect of IL-4 and TGF-beta in MS, were found to be confined to HLA-Dw2-positive patients.
|
9345450 |
1995 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Susceptibility is associated with the MHC class II region, especially HLA-DRB5*0101-HLA-DRB1*1501-HLA-DQA1*0102-HLA-DQB1*0602 haplotypes(hereafter DR2), which dominate genetic contribution to MS risk.
|
19380721 |
2009 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Dw2/DR2 phenotype, known to be associated with increased MS susceptibility, was also associated with a later onset of MS and more rapid progression of disease.
|
7061242 |
1982 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
The conclusions were: 1) There were no significantly higher occurrences of HLA-A3, B7, Dw2 or DRw2 in Japanese MS. 2) Japanese MS might nevertheless be associated with the human major histocompatibility complex, because HLA-B40 was significantly less frequent in MS and two anti HLA-DRw sera, 7w008 and 034, reacted positively more often against lymphocytes from MS patients.
|
80838 |
1978 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of HLA-DRB3 * 0202 (100%), HLA-DRB1 * 1302 (67%), HLA-DRB3 * 0301 (67%), and HLA-DQB1 * 0301 (67%) were significantly increased in children with multiple sclerosis and the frequencies of HLA-DRB1 * 1501 (40%) and HLA-DRB5 * 0101 (40%) were significantly increased in children with ADEM.
|
15201511 |
2004 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequencies of Properdin factor B allotypes were studied in 54 multiple sclerosis patients and 58 healthy control subjects, and the association of various phenotypes with HLA-Dw1 and Dw2 antigens (found with decreased and increased frequency in MS patients, respectively) was further studied.
|
6558078 |
1983 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DR2/Dw2 haplotype is associated with multiple sclerosis (MS) in the North American Caucasian population.
|
1723064 |
1991 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
The other components of the commonest DR2-containing haplotype of this region, HLA-A3-B7-DR2-Dw2, also tend to be present at higher frequency in MS patients.
|
3509722 |
1987 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
The possibility that the HLA-Dw2, BfS disequilibrium has resulted from a selective advantage conferred on the general community but at the expense of increasing susceptibility to MS should be considered.
|
91230 |
1979 |
|
HLA-DRB5
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The well-established association of DRw15, DQw6, Dw2 alleles and MS susceptibility was confirmed.
|
1361490 |
1992 |
|
HLA-DRB5
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was a trend indicating less cancer in families of MS patients possessing the HLA-B7 and DW2 histocompatibility antigens.
|
568746 |
1978 |