Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE We developed a competitive permeable peptide (CPP) to impair the formation of the Nm23-H1/h-Prune complex and demonstrated that CPP causes impairment of cell motility, substantial impairment of tumor growth and metastases formation. 23448979 2013
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE The mRNA expression level of metastasis suppressor genes including Nm23 was determined by qRT-PCR. 21838876 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE The human nucleoside diphosphate (NDP) kinase A, product of the NME1 gene also named NM23-H1, is known as a metastasis suppressor protein. 21484438 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE The mechanism of Nm23-H1 suppression of metastasis, however, is incompletely understood. 21713383 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Expression patterns of ER, HER2, and NM23-H1 in breast cancer patients with different menopausal status: correlations with metastasis. 21913743 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE The cell-permeable (CP)-NM23 inhibited metastasis-associated phenotypes in tumor cell lines, blocked the establishment of lung metastases, and cleared already established pulmonary metastases, significantly prolonging the survival of tumor-bearing animals. 21987726 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Thujone administration downregulated the expression of matrix metalloproteinase (MMP)-2, MMP-9, extracellular signal-regulated kinase (ERK)-1, ERK-2, and vascular endothelial growth factor (VEGF) and also upregulated the expression of nm-23, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 in the lung tissue of metastasis-induced animals. 21905822 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Evidence for a metastasis suppressor function of NME1 in vivo comes from crossing NME1 (-/-) mice with mice prone to develop hepatocellular carcinoma; the double transgenic mice present a higher incidence of lung metastases. 21562815 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Multiple mechanisms underlie metastasis suppressor function of NM23-H1 in melanoma. 21448569 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Although the NM23-H1 protein is implicated as a metastasis suppressor, the role of NM23-H2 appears to be less understood. 22192927 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Our findings suggest a correlation between high levels of NM23-H1 protein in the cytoplasm of the cells and progression of prostate cancer to metastasis, thus definitively identifying NM23-H1 as a new negative prognostic marker in prostate cancer. 21553004 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE nm23, a tumor metastasis suppressor gene, has been linked to protection against tumorigenesis and tumor metastasis. 22683585 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Several reviews have discussed NME1, however the role of NME2 appears to be relatively less understood in the context of metastasis suppression. 21556888 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Proteins that block metastasis without inhibiting primary tumor formation are known as metastasis suppressors; examples are NM23, Maspin, KAI1, KISS1, and MKK4. 21279956 2011
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23-H1 is a well-known tumor metastasis suppressor, which functions as a nucleoside-diphosphate kinase converting nucleoside diphosphates to nucleoside triphosphates with an expense of ATP. 20448457 2011
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Human nonmetastatic clone 23 Type 1 (nm23-H1) is demonstrated to have diverse roles in metastasis and survival for many cancers, which are probably caused via different impacts on its downstream genes. 21442621 2011
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE A key set of factors associated with this invasive phenotype is the nm23 family of over twenty metastasis-associated genes. 21846466 2011
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE The Nm23-H1 metastasis suppressor as a translational target. 20304626 2010
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE To analyze the prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients. 20671611 2010
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Metastasis suppressor function of NM23-H1 requires its 3'-5' exonuclease activity. 20209495 2010
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE The local invasive, non-metastatic phenotype of mesothelioma, could partly be due to overexpression of the known metastasis suppressors NME1 and NME2. 19662092 2010
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells. 20841469 2010
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE We thus provide evidence that the loss of Nm23-H1, an event suspected to promote metastasis, may additionally function at an earlier stage of tumor development to drive the acquisition of chromosomal instability. 20713695 2010
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nometastatic gene 23-H1 (NME1, also known as nm23-H1) is a wide-spectrum tumor metastasis suppressor gene that plays an important role in suppressing the invasion and metastasis of tumor cells. 20145075 2010
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1. 20101217 2010