Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 Biomarker disease BEFREE We further determined whether myocilin contributes to GC-OHT. 28167045 2017
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 GeneticVariation disease BEFREE This study does not confirm a role for genetic variants in the MYOC, NR3C1 and FKBP5 genes in the pathogenesis of corticosteroid-induced ocular hypertension. 24417561 2015
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 GeneticVariation disease BEFREE Inherited, disease-causing myocilin variants aggregate intracellularly instead of being secreted to the trabecular meshwork, which is a scenario toxic to trabecular meshwork cells and leads to early onset of ocular hypertension, the major risk factor for glaucoma. 24333014 2014
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 Biomarker disease BEFREE To identify myocilin (MYOC) and cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) mutations in a Spanish population with different clinical forms of familial glaucoma or ocular hypertension (OHT). 23922489 2013
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 GeneticVariation disease BEFREE A 34-year-old woman with marked ocular hypertension was found to carry Gln368STOP and Thr377Met MYOC mutations. 23304066 2012
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 Biomarker disease LHGDN Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma. 19148291 2009
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 Biomarker disease BEFREE We infer from the Drosophila model that MYOC-associated ocular hypertension in the human eye may result from aggregation of MYOC and induction of the UPR in trabecular meshwork cells. 19148291 2009
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 GeneticVariation disease BEFREE The promoter region and the three exons of MYOC were analyzed by direct PCR DNA sequencing in 40 OHT and 110 POAG unrelated patients. 17615537 2007
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 Biomarker disease RGD Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure. 17102796 2006
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 GeneticVariation disease BEFREE At present there is no evidence to link myocilin mutations and steroid-induced ocular hypertension or normal-tension glaucoma. 12504739 2003
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 GeneticVariation disease BEFREE Mutations in the MYOC gene were identified in patients presenting with highly variable phenotypes from normal through OHT to severe OAG. 11815346 2002
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 Biomarker disease BEFREE Therefore, myocilin may play an important pathogenic role in ocular hypertension in addition to its role in certain forms of POAG. 11431441 2001
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 Biomarker disease BEFREE The purpose of this study was to determine whether some variations in MYOC might be involved in steroid-induced ocular hypertension. 11133859 2001
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 Biomarker disease BEFREE There was strong evidence of genetic heterogeneity, four families being linked to GLC1A and two or three others being unlinked, depending on whether the complete OAG phenotype was analysed alone or jointly with OHT. 9222961 1997
Entrez Id: 4653
Gene Symbol: MYOC
MYOC 		0.400 Biomarker disease HPO
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1 		0.340 AlteredExpression disease BEFREE We provide the first evidence for the role of GR transactivation in regulating GC-mediated gene expression in the TM and in the development of GC-OHT. 31050723 2019
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1 		0.340 Biomarker disease BEFREE Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice. 29339763 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1 		0.340 Biomarker disease BEFREE This study does not confirm a role for genetic variants in the MYOC, NR3C1 and FKBP5 genes in the pathogenesis of corticosteroid-induced ocular hypertension. 24417561 2015
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1 		0.340 GeneticVariation disease BEFREE The variant N363S of glucocorticoid receptor in steroid-induced ocular hypertension in Hungarian patients treated with photorefractive keratectomy. 17563720 2007
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1 		0.340 GeneticVariation disease LHGDN The variant N363S of glucocorticoid receptor in steroid-induced ocular hypertension in Hungarian patients treated with photorefractive keratectomy. 17563720 2007
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1 		0.340 Biomarker disease CTD_human The variant N363S of glucocorticoid receptor in steroid-induced ocular hypertension in Hungarian patients treated with photorefractive keratectomy. 17563720 2007
Entrez Id: 1649
Gene Symbol: DDIT3
DDIT3 		0.300 Therapeutic disease CTD_human Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma. 24691439 2014
Entrez Id: 4312
Gene Symbol: MMP1
MMP1 		0.300 Therapeutic disease CTD_human Treatment of sheep steroid-induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus. 20089869 2010
Entrez Id: 4976
Gene Symbol: OPA1
OPA1 		0.210 Biomarker disease BEFREE To evaluate the difference in DCRs between OHT, HTG and NTG, a general linear model was used with sex, medications and group as fixed factors and bIOP and age as covariates. 30923134 2020
Entrez Id: 4976
Gene Symbol: OPA1
OPA1 		0.210 Biomarker disease RGD Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. 21220562 2011