Gene: LEP ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.100 Biomarker disease BEFREE However, neither a clear mechanism nor a direct clinical association linking leptin to OA has yet been established. 24036528 2013
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.100 Biomarker disease BEFREE Increased leptin has been the focus of a link between obesity and OA. 28956662 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.100 AlteredExpression disease BEFREE Our objective was to evaluate the relationship between the preoperative serum leptin levels and postoperative VTE incidence in osteoarthritis (OA) patients who underwent total knee arthroplasty (TKA) at our institute.We conducted a prospective and cross-sectional study in these OA patients from March 2014 to March 2016. 29794796 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.100 AlteredExpression disease BEFREE Therefore, in the present study, we investigated the hypothesis that hypoxia may drive the expression of leptin and DKK2 in OA Obs. 25312721 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.100 Biomarker disease BEFREE This Review discusses the latest findings regarding the role of leptin in the immune system and metabolism, with particular emphasis on its effect on autoimmune and/or inflammatory rheumatic diseases, such as rheumatoid arthritis and osteoarthritis. 28053336 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.100 Biomarker disease BEFREE DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis. 26751999 2016