×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
Biomarker
disease
BEFREE
Treatment of nude mice with the retroviral p53 vector resulted in a significant inhibition of growth of the primary pancreatic tumor , as well as the peritoneal tumor deposits, compared with the LXSN control vector.
9706132
1998
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
GeneticVariation
disease
BEFREE
Mutation of the p53 tumor suppressor gene is found in a large number of exocrine pancreatic tumors .
9436856
1998
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
Biomarker
disease
BEFREE
This is the first time that concomitant point mutations in c-N-ras and p53 have been found in a neuroendocrine pancreatic tumor .
9042254
1997
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
AlteredExpression
disease
BEFREE
With the aid of a newly developed target unmasking fluid (TUF), p53 overexpression was visualized by immunohistochemistry on recent and archival paraffin-embedded tissue samples of colon, stomach, and pancreas neoplasms .
8434637
1993
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
Biomarker
disease
HPO
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
CausalMutation
disease
CGI
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
Biomarker
disease
CTD_human
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
BEFREE
This can have implications for screening and for the diagnosis of pancreatic neoplasms in carriers of germline CDKN2A mutations.
31261289
2019
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
CTD_human
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
26098869
2015
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
BEFREE
In this study, three patients who developed both melanoma and intraepithelial neoplasia of the pancreas were tested for CDKN2A mutations and deletions, and investigated for rare germline copy number variations (CNVs).
24984283
2014
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
BEFREE
In LSL-Kras(G12D )/Pdx-1-Cre/Ink4a /Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor -free survival.
23980075
2013
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
BEFREE
The INK4a -ARF locus plays a central role in the development of pancreatic tumors as evidenced by the fact that up to 98% of pancreatic tumor specimens harbored genetic alterations at the INK4a -ARF locus.
23727582
2013
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
LHGDN
Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland.
18714178
2008
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
LHGDN
Genetic testing in familial melanoma: uptake and implications.
18613292
2008
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
LHGDN
Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs.
17106238
2006
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
LHGDN
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma.
15985168
2005
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
AlteredExpression
disease
LHGDN
Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes.
15336553
2004
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
AlteredExpression
disease
BEFREE
The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity.
15309028
2004
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
LHGDN
INK4/ARF germline alterations in pancreatic cancer patients.
14679123
2004
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
LHGDN
Familial melanoma, pancreatic cancer and germline CDKN2A mutations.
15146471
2004
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
BEFREE
Delivery of ALSV-A-based RCAS vectors encoding either mouse polyoma virus middle T antigen (PyMT) or c-Myc to elastase-tv-a transgenic, Ink4a /Arf null mice induced the formation of pancreatic tumors .
14681205
2003
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
BEFREE
The p16INK4a -/retinoblastoma tumour-suppressive pathway has been shown to be involved in the development of near to all pancreatic neoplasms . p14ARF is another tumour suppressor located in the immediate neighbourhood of p16INK4a .
12610506
2003
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
LHGDN
High prevalence of the G101W germline mutation in the CDKN2A (P16(ink4a)) gene in 62 Italian malignant melanoma families.
11807902
2002
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
BEFREE
Experiments on subcutaneous pancreatic xenografts demonstrated the effectiveness of p16 in the inhibition of pancreatic tumor growth in vivo.
11687897
2001
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
CTD_human
Novel germline p16(INK4) allele (Asp145Cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148. Online.
10627132
1998