Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2588
Gene Symbol: GALNS
GALNS 		0.010 GeneticVariation disease BEFREE Study 2 extends the validation of the GAS-G-SF to a clinical sample (<i>N</i> = 156; 62 patients with heart disease, 94 patients with Parkinson's disease). 31625412 2020
Entrez Id: 2899
Gene Symbol: GRIK3
GRIK3 		0.010 Biomarker disease BEFREE Given the expression of kainate receptor subunits GluK1-GluK3 in key PD-related brain regions, it has been suggested that GluK1-GluK3 may contribute to excitotoxic cell loss. 31513786 2020
Entrez Id: 2146
Gene Symbol: EZH2
EZH2 		0.010 Biomarker disease BEFREE Recuperative effect of metformin loaded polydopamine nanoformulation promoting EZH2 mediated proteasomal degradation of phospho-α-synuclein in Parkinson's disease model. 31476446 2020
Entrez Id: 406924
Gene Symbol: MIR134
MIR134 		0.010 Biomarker disease BEFREE Circular RNA circDLGAP4 exerts neuroprotective effects via modulating miR-134-5p/CREB pathway in Parkinson's disease. 31761328 2020
Entrez Id: 9780
Gene Symbol: PIEZO1
PIEZO1 		0.010 GeneticVariation disease BEFREE We further demonstrate melanoma and PD-inferred gene expression to overlap across tissues (correlation: 0.14, 95% CI 0.06 to 0.22; P = 7.87 × 10<sup>-04</sup>) and highlight seven genes including PIEZO1, TRAPPC2L, and SOX6 as potential mediators of the genetic correlation between melanoma and PD. 31845298 2020
Entrez Id: 285755
Gene Symbol: PPIL6
PPIL6 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 57486
Gene Symbol: NLN
NLN 		0.010 AlteredExpression disease BEFREE All of the parameters investigated showed inverse correlations with PD severity, and there were significant differences among the levels of severity, as well as between the PD and control groups, in terms of the MIP, MEP, FVC, FEV1, and FEF25-75%. 31576908 2020
Entrez Id: 4820
Gene Symbol: NKTR
NKTR 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 110366354
Gene Symbol: LOC110366354
LOC110366354 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: AD: Alzheimer disease; BM: basement membrane; BWM: body wall muscle; CEP: cephalic sensilla; CLEM: correlative light and electron microscopy; CTNS-1: cystinosin (lysosomal protein) homolog; DA: dopaminergic; DAF-2: abnormal dauer formation; ECM: extracellular matrix; FLIM: fluorescence lifetime imaging microscopy; fps: frames per second; GFP: green fluorescent protein; HPF: high pressure freezing; IGF1: insulin-like growth factor 1; INS: insulin; KD: knockdown; LMP: lysosomal membrane permeabilization; MVB: multivesicular body; NOC: nocodazole; PD: Parkinson disease; RFP: red fluorescent protein; RNAi: RNA interference; sfGFP: superfolder GFP; SNCA: synuclein alpha; TEM: transmission electron microscopy; TNTs: tunneling nanotubes; TCSPC: time correlated single photon counting; YFP: yellow fluorescent protein. 31354022 2020
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3 		0.010 Biomarker disease BEFREE Collectively, our findings support a novel role for the anti-inflammatory capacity of the MasR axis to prove potential therapeutic relevance in PD via the upregulation/activation of MasR-dependent STAT3/SOCS3 cascade to negatively control the HMGB-1/RAGE/NF-κB axis hindering PD associated neuro-inflammation along with DA depletion and motor deficits. 31669235 2020
Entrez Id: 7939
Gene Symbol: LAP
LAP 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: 3-MA: 3-methyladenine; AD: Alzheimer disease; ATG: autophagy-related; BECN1: beclin 1; BM: bone marrow; CD: cluster of differentiation; EAE: experimental autoimmune encephalomyelitis; IL: interleukin; INF: interferon; LAP: LC3-associated phagocytosis; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MSCs: mesenchymal stem cells; MTOR: mechanistic target of rapamycin kinase; PD: Parkinson disease; PtdIns3K: class III phosphatidylinositol 3-kinase; ROS: reactive oxygen species; SLE: systemic lupus erythematosus; SQSTM1: sequestosome 1; TBI: traumatic brain injury; TGF: transforming growth factor; TNF: tumor necrosis factor. 31185790 2020
Entrez Id: 506
Gene Symbol: ATP5F1B
ATP5F1B 		0.010 Biomarker disease BEFREE Abbreviations : ACTB: actin beta; ATP5F1B: ATP synthase F1 subunit beta; CALCOCO2: calcium binding and coiled-coil domain 2; CCCP: carbonyl cyanide m-chlorophenylhydrazone; Co-IP: co-immunoprecipitation; EBSS: Earle's balanced salt solution; GFP: green fluorescent protein; HSPD1: heat shock protein family D (Hsp60) member 1; LAMP1: lysosomal associated membrane protein 1; LRRK2: leucine rich repeat kinase 2; IF: immunofluorescence; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MFN2: mitofusin 2; OMM: outer mitochondrial membrane; OPTN: optineurin; PD: Parkinson disease; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; RHOT1: ras homolog family member T1; ROS: reactive oxygen species; TBK1: TANK binding kinase 1; WB: western blot. 30945962 2020
Entrez Id: 22839
Gene Symbol: DLGAP4
DLGAP4 		0.010 AlteredExpression disease BEFREE Here, our results showed that circDLGAP4 expression was decreased in MPTP-induced PD mouse model and MPP<sup>+</sup>-induced PD cell models. 31761328 2020
Entrez Id: 25819
Gene Symbol: NOCT
NOCT 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: AD: Alzheimer disease; BM: basement membrane; BWM: body wall muscle; CEP: cephalic sensilla; CLEM: correlative light and electron microscopy; CTNS-1: cystinosin (lysosomal protein) homolog; DA: dopaminergic; DAF-2: abnormal dauer formation; ECM: extracellular matrix; FLIM: fluorescence lifetime imaging microscopy; fps: frames per second; GFP: green fluorescent protein; HPF: high pressure freezing; IGF1: insulin-like growth factor 1; INS: insulin; KD: knockdown; LMP: lysosomal membrane permeabilization; MVB: multivesicular body; NOC: nocodazole; PD: Parkinson disease; RFP: red fluorescent protein; RNAi: RNA interference; sfGFP: superfolder GFP; SNCA: synuclein alpha; TEM: transmission electron microscopy; TNTs: tunneling nanotubes; TCSPC: time correlated single photon counting; YFP: yellow fluorescent protein. 31354022 2020
Entrez Id: 116150
Gene Symbol: NUS1
NUS1 		0.010 GeneticVariation disease BEFREE These results suggested that NUS1 mutation may not be a common genetic factor for Chinese patients with sporadic PD. 31582230 2020
Entrez Id: 2358
Gene Symbol: FPR2
FPR2 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: AD: Alzheimer disease; BM: basement membrane; BWM: body wall muscle; CEP: cephalic sensilla; CLEM: correlative light and electron microscopy; CTNS-1: cystinosin (lysosomal protein) homolog; DA: dopaminergic; DAF-2: abnormal dauer formation; ECM: extracellular matrix; FLIM: fluorescence lifetime imaging microscopy; fps: frames per second; GFP: green fluorescent protein; HPF: high pressure freezing; IGF1: insulin-like growth factor 1; INS: insulin; KD: knockdown; LMP: lysosomal membrane permeabilization; MVB: multivesicular body; NOC: nocodazole; PD: Parkinson disease; RFP: red fluorescent protein; RNAi: RNA interference; sfGFP: superfolder GFP; SNCA: synuclein alpha; TEM: transmission electron microscopy; TNTs: tunneling nanotubes; TCSPC: time correlated single photon counting; YFP: yellow fluorescent protein. 31354022 2020
Entrez Id: 23759
Gene Symbol: PPIL2
PPIL2 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 197259
Gene Symbol: MLKL
MLKL 		0.010 Biomarker disease BEFREE Downregulating the expression of RIP1, RIP3, or MLKL can significantly attenuate MPTP-induced PD. 31506635 2020
Entrez Id: 7386
Gene Symbol: UQCRFS1
UQCRFS1 		0.010 AlteredExpression disease BEFREE Downregulating the expression of RIP1, RIP3, or MLKL can significantly attenuate MPTP-induced PD. 31506635 2020
Entrez Id: 79447
Gene Symbol: PAGR1
PAGR1 		0.010 GeneticVariation disease BEFREE Study 2 extends the validation of the GAS-G-SF to a clinical sample (<i>N</i> = 156; 62 patients with heart disease, 94 patients with Parkinson's disease). 31625412 2020
Entrez Id: 79661
Gene Symbol: NEIL1
NEIL1 		0.010 Biomarker disease BEFREE In the present study, we established mouse model with PD using 6-hydroxydopamine (6-OHDA) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to explore the effects of NEIL1 on PD development. 31653343 2020
Entrez Id: 100188881
Gene Symbol: MFT2
MFT2 		0.010 AlteredExpression disease BEFREE <b>Abbreviations</b>: AD: Alzheimer disease; BM: basement membrane; BWM: body wall muscle; CEP: cephalic sensilla; CLEM: correlative light and electron microscopy; CTNS-1: cystinosin (lysosomal protein) homolog; DA: dopaminergic; DAF-2: abnormal dauer formation; ECM: extracellular matrix; FLIM: fluorescence lifetime imaging microscopy; fps: frames per second; GFP: green fluorescent protein; HPF: high pressure freezing; IGF1: insulin-like growth factor 1; INS: insulin; KD: knockdown; LMP: lysosomal membrane permeabilization; MVB: multivesicular body; NOC: nocodazole; PD: Parkinson disease; RFP: red fluorescent protein; RNAi: RNA interference; sfGFP: superfolder GFP; SNCA: synuclein alpha; TEM: transmission electron microscopy; TNTs: tunneling nanotubes; TCSPC: time correlated single photon counting; YFP: yellow fluorescent protein. 31354022 2020
Entrez Id: 4316
Gene Symbol: MMP7
MMP7 		0.010 AlteredExpression disease BEFREE Taken together, our results suggest a potential orchestrated association between an increase in Mmp-7 and Mmp-9/Reck expression ratios in the substantia nigra and a possible positive effect on cognitive performance in subjects affected by PD. 31493243 2020
Entrez Id: 85313
Gene Symbol: PPIL4
PPIL4 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020