HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The strength of the allele associations to PV is in agreement with the view that the main PV susceptibility genes are the DRB1*0402 and DQB1*0503 alleles.
|
9008308 |
1996 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that HLA DRB1*04 and DRB1*14 alleles, and HLA DRB1*04/DQB1*03 and HLA DRB1*14/DQB1*05 haplotypes are genetic markers for general susceptibility to PV in the Turkish population.
|
20507388 |
2010 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The HLA DRB1* and DQB1* alleles influence susceptibility to PV and may contribute to PV severity and type.
|
24602055 |
2015 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The DR and DQ molecular alleles positively associated with PV were two different haplotypes: DRb1* 0402/DQb1* 0302 and DRb1* 1401/DQb1* 0503.
|
12196893 |
2003 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*04:02 and DQB1*05:03 alleles are associated with pemphigus vulgaris in our study as well as in various populations.
|
28197992 |
2017 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We compared high resolution MHC class II alleles and haplotype frequencies (HLA-DRB, DQA1 and DQB1) in 37 patients with PV to 89 haplotypes of normal relatives from New Delhi and Ahmedabad.
|
9008309 |
1996 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A fine-mapping analysis of PV risk in the major histocompatibility complex region showed three independent variants predisposed to PV using stepwise analysis: HLA-DRB1*14:04 (P = 2.47 × 10<sup>-38</sup>, odds ratio = 6.28), rs7454108 at the TAP2 gene (P = 2.78 × 10<sup>-12</sup>, odds ratio = 3.25), and rs1051336 at the HLA-DRA gene (P = 3.06 × 10<sup>-6</sup>, odds ratio = 0.33).
|
29857070 |
2018 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Patients that carry both the PV-associated human leukocyte antigen (HLA) alleles DRB1*0402 and DQB1*0503, or DQB1*0503 alone show a low prevalence of anti-TPO (A.R.
|
29675021 |
2018 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, while <i>HLA-DRB1*04:02</i> confers susceptibility to PV, this and other alleles that encode the same sequence motif in the 70-74 region of the DR beta chain are protective against RA.
|
27814654 |
2017 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris.
|
22437316 |
2012 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that an HLA-DRB1*1405 (DQB1*0503) haplotype may confer susceptibility to both PV and PF, and that genetic susceptibility alone is not always responsible for the clinical phenotype and autoantibody profile.
|
21352303 |
2011 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Since 86% (19 of 22) of DRw6+ patients contain the DQB1.3 allele (vs. 3% of controls), whereas 64% (14 of 22) contain the DRB1 allele 6B (vs. 6% of the controls), we conclude that most of the DRw6 susceptibility to PV can be accounted for by the DQ beta chain.
|
2503828 |
1989 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Dsg3-specific T-cell responses were detected in PV patients but also in healthy individuals who were either carriers of the PV-associated DRB1*0402 allele or alleles that share similar or identical peptide binding motifs to DRB1*0402.
|
12878355 |
2003 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thus our findings, together with previous HLA studies on pemphigus vulgaris patients of different ethnic groups, suggest that HLA-DRB1*04 and DRB1*14 alleles are commonly associated with pemphigus vulgaris across racial barriers.
|
9347787 |
1997 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All DRB1*04 and DRB1*14 alleles carried by PV patients with different ethnic backgrounds reported to date, including DRB1*0402, which confers strong susceptibility to PV among Jewish populations, have amino acid residues Phe26, Leu67 or Ile67, and Val86, as well as hydrophilic amino acid residues at positions 70 and 71 of the DRB1 beta chain.
|
9714477 |
1998 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Taking together these data, we can conclude that, in the Spanish population, PV is preferentially and strongly associated with HLA-DRB1*0402, whereas DRB1*13 seems to confer a protective effect in our population.
|
9802608 |
1998 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There is a close immunogenetic association of PV with the human leukocyte antigen (HLA) class II alleles, HLA-DRB1*04:02 and HLA-DQB1*05:03.
|
29313220 |
2018 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results support the hypothesis that the DRB1*0402 without DQB1*0302 is the most relevant HLA-DRB1 allele responsible for the pathogenesis of pemphigus in Venezuelan patients with PV and discard the DQB1*0302 influence observed in other populations.
|
17389015 |
2007 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Subjects were typed for HLA class II DRB1 and DQB1 alleles, and categorized as HLA-matched if homozygous or heterozygous for either one of the known PV-susceptibility alleles, DRB1*0402 and DQB1*0503.
|
28174139 |
2017 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
DRB1*04:02, DRB1*14:04, DQB1*03:02 and DQB1*05:03 alleles were shown to be strongly associated with PV (P adj = 1.63 × 10(-12), 5.20 × 10(-7), 1.28 × 10(-6), and 4.44 × 10(-5), respectively).
|
27072514 |
2016 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
We show that CD4(+) T cells recognizing immunodominant Dsg3 epitopes in the context of the PV-associated HLA-DRB1*04:02 induce the secretion of Dsg3-specific IgG in vivo.
|
25252957 |
2014 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
There was a significant association between HLA-DRB1*14 and HLA-DQB1*05 and pemphigus vulgaris in our patients.
|
29582787 |
2018 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The occurrence of PV is positively associated with HLA-DRB1*14 and HLA-DRB1*0402 but negatively associated with HLA-DRB1*11 in the Syrian population.
|
24697292 |
2014 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In addition, DRB1*14 was demonstrated to be a second independent variants (P = 4.2 × 10<sup>-63</sup> , OR = 35.47) for PV, while DRB1*04:06 was demonstrated to be the second independent signal (P = 7.44 × 10<sup>-13</sup> , OR = 5.58) for PF.
|
30169916 |
2019 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
There was a significant association of either DQB1*0503 or DRB1*1405 with PV, and a negative association of either DQA1*0103 or DQB1*0601 with PV was found.
|
7871526 |
1994 |