HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
DRB1*04:02, DRB1*14:04, DQB1*03:02 and DQB1*05:03 alleles were shown to be strongly associated with PV (P adj = 1.63 × 10(-12), 5.20 × 10(-7), 1.28 × 10(-6), and 4.44 × 10(-5), respectively).
|
27072514 |
2016 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The strength of the allele associations to PV is in agreement with the view that the main PV susceptibility genes are the DRB1*0402 and DQB1*0503 alleles.
|
9008308 |
1996 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that HLA DRB1*04 and DRB1*14 alleles, and HLA DRB1*04/DQB1*03 and HLA DRB1*14/DQB1*05 haplotypes are genetic markers for general susceptibility to PV in the Turkish population.
|
20507388 |
2010 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The HLA DRB1* and DQB1* alleles influence susceptibility to PV and may contribute to PV severity and type.
|
24602055 |
2015 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
We show that CD4(+) T cells recognizing immunodominant Dsg3 epitopes in the context of the PV-associated HLA-DRB1*04:02 induce the secretion of Dsg3-specific IgG in vivo.
|
25252957 |
2014 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
There was a significant association between HLA-DRB1*14 and HLA-DQB1*05 and pemphigus vulgaris in our patients.
|
29582787 |
2018 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The occurrence of PV is positively associated with HLA-DRB1*14 and HLA-DRB1*0402 but negatively associated with HLA-DRB1*11 in the Syrian population.
|
24697292 |
2014 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The DR and DQ molecular alleles positively associated with PV were two different haplotypes: DRb1* 0402/DQb1* 0302 and DRb1* 1401/DQb1* 0503.
|
12196893 |
2003 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In addition, DRB1*14 was demonstrated to be a second independent variants (P = 4.2 × 10<sup>-63</sup> , OR = 35.47) for PV, while DRB1*04:06 was demonstrated to be the second independent signal (P = 7.44 × 10<sup>-13</sup> , OR = 5.58) for PF.
|
30169916 |
2019 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*04:02 and DQB1*05:03 alleles are associated with pemphigus vulgaris in our study as well as in various populations.
|
28197992 |
2017 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We compared high resolution MHC class II alleles and haplotype frequencies (HLA-DRB, DQA1 and DQB1) in 37 patients with PV to 89 haplotypes of normal relatives from New Delhi and Ahmedabad.
|
9008309 |
1996 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
There was a significant association of either DQB1*0503 or DRB1*1405 with PV, and a negative association of either DQA1*0103 or DQB1*0601 with PV was found.
|
7871526 |
1994 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A fine-mapping analysis of PV risk in the major histocompatibility complex region showed three independent variants predisposed to PV using stepwise analysis: HLA-DRB1*14:04 (P = 2.47 × 10<sup>-38</sup>, odds ratio = 6.28), rs7454108 at the TAP2 gene (P = 2.78 × 10<sup>-12</sup>, odds ratio = 3.25), and rs1051336 at the HLA-DRA gene (P = 3.06 × 10<sup>-6</sup>, odds ratio = 0.33).
|
29857070 |
2018 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Patients that carry both the PV-associated human leukocyte antigen (HLA) alleles DRB1*0402 and DQB1*0503, or DQB1*0503 alone show a low prevalence of anti-TPO (A.R.
|
29675021 |
2018 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, while <i>HLA-DRB1*04:02</i> confers susceptibility to PV, this and other alleles that encode the same sequence motif in the 70-74 region of the DR beta chain are protective against RA.
|
27814654 |
2017 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that DRB1*04, DRB1*08 and DRB1*14 are statistically significant susceptibility factors for PV.
|
22564118 |
2012 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Studies showed that the associated HLA haplotype in Jewish pemphigus vulgaris (PV) patients is HLA-B38, DRB1*0402, and DQB1*0302; or HLA-B35, DRB1*0402, and DQB1*0302.
|
15009804 |
2004 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Their parents and five siblings had only one or none of these two haplotypes in combination with the alleles or haplotypes associated with resistance to PV (DRB1∗07:01-DQA1∗02:01-DQB1∗02:02 and DRB1∗13:01-DQA1∗01:03-DQB1∗06:03).
|
27177496 |
2016 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taking advantage of an area where pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are prevalent in the northeastern region of the state of São Paulo, Southeastern Brazil, we have studied the HLA class I (A, B and C) and class II (DRB1 and DQA1/DQB1) profiles in 86 and 83 patients with PF and PV, respectively, as compared with 1592 controls from the same region.
|
27178774 |
2016 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Therefore, at least in Italian patients, pemphigus vulgaris and pemphigus foliaceus share DRB1*1401 and DQB1*0503, as susceptible human leukocyte antigen alleles, whereas DRB1*0402 is only found associated with pemphigus vulgaris.
|
10417627 |
1999 |
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
We confirmed the previously reported associations between HLA class II alleles and PV and described a new association between PV and DRB1*14:54.
|
23551624 |
2013 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that an HLA-DRB1*1405 (DQB1*0503) haplotype may confer susceptibility to both PV and PF, and that genetic susceptibility alone is not always responsible for the clinical phenotype and autoantibody profile.
|
21352303 |
2011 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Since 86% (19 of 22) of DRw6+ patients contain the DQB1.3 allele (vs. 3% of controls), whereas 64% (14 of 22) contain the DRB1 allele 6B (vs. 6% of the controls), we conclude that most of the DRw6 susceptibility to PV can be accounted for by the DQ beta chain.
|
2503828 |
1989 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Dsg3-specific T-cell responses were detected in PV patients but also in healthy individuals who were either carriers of the PV-associated DRB1*0402 allele or alleles that share similar or identical peptide binding motifs to DRB1*0402.
|
12878355 |
2003 |
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thus our findings, together with previous HLA studies on pemphigus vulgaris patients of different ethnic groups, suggest that HLA-DRB1*04 and DRB1*14 alleles are commonly associated with pemphigus vulgaris across racial barriers.
|
9347787 |
1997 |