Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9670
Gene Symbol: IPO13
IPO13 		0.010 AlteredExpression disease BEFREE IPO13 activity was significantly increased in the basal layer of the epithelium of the pterygium. 23559854 2013
Entrez Id: 7015
Gene Symbol: TERT
TERT 		0.010 AlteredExpression disease BEFREE Telomerase reverse transcriptase was expressed, and p53 and p16 levels were reduced in immortalized pterygium fibroblast cells. 24012806 2013
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12 		0.020 AlteredExpression disease BEFREE Stromal cell-derived factor 1 levels in cultured pterygial fibroblasts correlated positively with the severity of pterygia. 24114538 2013
Entrez Id: 6279
Gene Symbol: S100A8
S100A8 		0.020 Biomarker disease BEFREE S100A8/9 may be an upstream trigger for inflammation and other disease pathways in pterygium. 24825356 2014
Entrez Id: 56955
Gene Symbol: MEPE
MEPE 		0.010 Biomarker disease BEFREE Of 45 pterygia samples with acceptable DNA quality, 29 (64.4%) were positive for HPV DNA, whereas all the normal conjunctiva swabs were HPV negative. 25043991 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.030 AlteredExpression disease BEFREE TNF-α upregulates HIF-1α expression in pterygium fibroblasts and enhances their susceptibility to VEGF independent of hypoxia. 28803935 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.020 AlteredExpression disease BEFREE HIF-1α and VEGF expression were detected in 6/6 surgically excised pterygia and localized to CjECs. 28873177 2017
Entrez Id: 3490
Gene Symbol: IGFBP7
IGFBP7 		0.010 AlteredExpression disease BEFREE IGFBP-7 expression was determined in normal (n=83) and conjunctivalized (n=52) mouse corneas with experimentally-induced LSCD, and in cadaveric normal human corneas (n=7) and human pterygia (n=15); a disease characterized by the invasion of a conjunctivalized, fibrovascular pannus. 31125784 2019
Entrez Id: 8482
Gene Symbol: SEMA7A
SEMA7A 		0.010 AlteredExpression disease BEFREE Semaphorin 7a was highly expressed in the primary pterygium and recurrent pterygium samples than that of the normal conjunctival tissue. 31236342 2019
Entrez Id: 407025
Gene Symbol: MIR29B2
MIR29B2 		0.010 Biomarker disease BEFREE MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium. 31341891 2019
Entrez Id: 407024
Gene Symbol: MIR29B1
MIR29B1 		0.010 Biomarker disease BEFREE MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium. 31341891 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12 		0.020 Biomarker disease BEFREE SDF-1/CXCR4 signaling may play a vital role in pterygium and shorter axial length. 31714404 2020
Entrez Id: 4312
Gene Symbol: MMP1
MMP1 		0.030 Biomarker disease BEFREE A dose- and time-dependent increase in MMP-1 was observed when pterygium epithelial cells were exposed to UVB with no significant modulation of inhibitor activity. 14578390 2003
Entrez Id: 6707
Gene Symbol: SPRR3
SPRR3 		0.010 Biomarker disease BEFREE A gene signature consisting of 11 DEGs were found to be shared by pterygium and MGD (SPRR3, SERPINB13, NMU, KRT10, IL37, KRT6B, PI3, S100A2, MAL, AURKA, and RGCC), and bioinformatics analyses showed that these overlapped DEGs were significantly enriched in pathways related to keratinization, cell-cycle regulation, and formation of the cornified envelope. 31373692 2019
Entrez Id: 54101
Gene Symbol: RIPK4
RIPK4 		0.030 Biomarker disease BEFREE A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes. 25430793 2015
Entrez Id: 3664
Gene Symbol: IRF6
IRF6 		0.090 Biomarker disease BEFREE A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes. 25430793 2015
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.020 AlteredExpression disease BEFREE A significant correlation between the TRPV1 and TRPV3 expression levels (P<0.001) was detected independently of pterygium recurrence. 28849159 2017
Entrez Id: 162514
Gene Symbol: TRPV3
TRPV3 		0.010 AlteredExpression disease BEFREE A significant correlation between the TRPV1 and TRPV3 expression levels (P<0.001) was detected independently of pterygium recurrence. 28849159 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.010 Biomarker disease BEFREE A statistically significant difference was found between the pterygium and control groups for the ACE I/D polymorphism (p<0.001). 25341451 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 AlteredExpression disease BEFREE Abnormal p53 expression in the epithelium of primary and recurrent pterygium specimens suggests that pterygium is a growth disorder rather than a degeneration. 9063255 1997
Entrez Id: 2475
Gene Symbol: MTOR
MTOR 		0.010 AlteredExpression disease BEFREE Additionally, mTOR expression was significantly correlated with α-SMA expression (ρ = 0.269, p = 0.031) in pterygium. 28623647 2017
Entrez Id: 6606
Gene Symbol: SMN1
SMN1 		0.030 AlteredExpression disease BEFREE Additionally, mTOR expression was significantly correlated with α-SMA expression (ρ = 0.269, p = 0.031) in pterygium. 28623647 2017
Entrez Id: 6607
Gene Symbol: SMN2
SMN2 		0.030 AlteredExpression disease BEFREE Additionally, mTOR expression was significantly correlated with α-SMA expression (ρ = 0.269, p = 0.031) in pterygium. 28623647 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 AlteredExpression disease BEFREE After p53 protein was found to be abnormally expressed in the epithelium, researchers suggested that a pterygium may be a tumor, but additional evidence is required to support this hypothesis. 17149367 2006
Entrez Id: 218
Gene Symbol: ALDH3A1
ALDH3A1 		0.010 AlteredExpression disease BEFREE Among these genes, we chose three proteins, aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1), protein disulfide-isomerase A3 (PDIA3), and peroxiredoxin-2 (PRDX2), that were significantly upregulated in pterygium and further increased in recurrent pterygium. 25221425 2014