Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.500 | Biomarker | disease | CTD_human | In this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice. | 20701826 | 2011 | ||||
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0.500 | Biomarker | disease | CTD_human | Acute effects of delta9-tetrahydrocannabinol on the auditory evoked mismatch negativity are modulated by the NRG1 gene. | 20582876 | 2010 | ||||
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0.500 | Biomarker | disease | CTD_human | Therefore, genes associated with schizophrenia, including neuregulin-1 (NRG1), catechol-O-methyltranferase (COMT) and disrupted-in-schizophrenia-1 (DISC1), may play a role in modulating the physiological and psychological effects of pain stimuli in such patients. | 20561508 | 2010 | ||||
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0.500 | Biomarker | disease | CTD_human | Human and animal research indicates that neuregulin 1 (Nrg1) is a susceptibility gene for schizophrenia. | 17333138 | 2007 | ||||
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0.500 | Biomarker | disease | CTD_human | Furthermore, we showed that NRG1+/- mutant mice display behavioral abnormalities that are reversed by clozapine, an atypical antipsychotic drug used for the treatment of schizophrenia. | 17460065 | 2007 | ||||
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0.500 | Biomarker | disease | CTD_human | Consistent with Nrg1 HET mice exhibiting a schizophrenia-related phenotype, these mice expressed greater drug-free levels of c-Fos in two regions thought to be involved in schizophrenia, the shell of the nucleus accumbens and the lateral septum. | 17905522 | 2007 | ||||
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0.500 | Biomarker | disease | CTD_human | We also demonstrate that the behavioral phenotypes of the NRG1 hypomorphs are partially reversible with clozapine, an atypical antipsychotic drug used to treat schizophrenia. | 12145742 | 2002 |