HLA-DPB1
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
No identical variant in the other haplotype including DPB1*09:01 was observed, though that haplotype also showed a significant association (P = 8.5 × 10<sup>-22</sup>; OR = 4.3) with systemic sclerosis.
|
28506627 |
2017 |
HLA-DPB1
|
0.180 |
Biomarker
|
disease |
BEFREE |
However, there was a significant association between DRB1*01:01, DRB1*10:01, DQB1*05:01, and DPB1*04:02 and the susceptibility to SSc with ACA.
|
27116456 |
2016 |
HLA-DPB1
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Negatively-charged amino acids at the peptide-binding pocket of HLA-DPB1 alleles are associated with susceptibility to anti-topoisomerase I-positive systemic sclerosis.
|
27208855 |
2016 |
HLA-DPB1
|
0.180 |
Biomarker
|
disease |
BEFREE |
Association of HLA-DPB1 with scleroderma and its clinical features in Chinese population.
|
24498086 |
2014 |
HLA-DPB1
|
0.180 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
|
20383147 |
2010 |
HLA-DPB1
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
To determine human leucocyte antigen-class II (HLA-class II) (DRB1, DQB1, DQA1 and DPB1) alleles, haplotypes and shared epitopes associated with scleroderma (systemic sclerosis (SSc)) and its subphenotypes in a large multi-ethnic US cohort by a case-control association study.
|
19596691 |
2010 |
HLA-DPB1
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
The confirmatory studies in US Caucasians indicate that specific SNPs of HLA-DPB1 and/or DPB2 are strongly associated with US Caucasian patients with SSc who are positive for anti-DNA topoisomerase I or anticentromere autoantibodies.
|
19950302 |
2009 |
HLA-DPB1
|
0.180 |
GeneticVariation
|
disease |
GWASDB |
HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans.
|
19950302 |
2009 |
HLA-DPB1
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
An extended HLA DR2 (DRB1*1602, DQA1*0501, DQB1*0301, DPB1*1301) haplotype that includes the class I and III regions was identified which was significantly associated with scleroderma in the Oklahoma Choctaw.
|
10082433 |
1999 |
HLA-DPB1
|
0.180 |
Biomarker
|
disease |
BEFREE |
Statistical analysis revealed a significantly increased frequency of DPB1*1301(p=0.0001, corrected p=0.011) in idiopathic anti-Scl-70-positive systemic sclerosis cases when compared with unexposed controls.
|
8620089 |
1996 |