×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
BEFREE
Despite advances with traditional single genes molecular research, including rare mutations in BRCA1/2 and CDH1 for primary prevention and trastuzumab for treating HER2-overexpressing breast and gastric tumors , overall, treatment failure and death rates are still alarmingly high.
20975737
2011
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
BEFREE
This multicenter study evaluated the association of 9 single nucleotide polymorphisms (SNP) in AXIN2 and CDH1 , representing genes consistently altered in breast and gastric tumors , with NSCL ± P in 223 trios (father, mother and patient with NSCL ± P) by transmission disequilibrium test (TDT).
28376813
2017
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
CTD_human
Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer.
10072428
1999
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
CTD_human
Chronic aspirin use suppresses CDH1 methylation in human gastric mucosa.
19184424
2010
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
CTD_human
Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands.
12588804
2003
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
CTD_human
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
24816253
2014
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
CTD_human
Germline CDH1 deletions in hereditary diffuse gastric cancer families.
19168852
2009
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
CTD_human
E-cadherin germline mutations in familial gastric cancer.
9537325
1998
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
CausalMutation
group
CGI
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer.
17545690
2007
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
LHGDN
Clinical significance of dysadherin expression in gastric cancer patients.
15102690
2004
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria.
15235021
2004
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
A novel mutation in the E-cadherin gene in the first family with hereditary diffuse gastric cancer reported in Spain.
16870389
2006
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
AlteredExpression
group
LHGDN
The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.
18427545
2008
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
LHGDN
Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer.
18312357
2008
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
PosttranslationalModification
group
LHGDN
Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer.
15102685
2004
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
LHGDN
Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of beta-catenin.
16132582
2005
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
Association between CDH1 haplotypes and gastric cancer risk in a Japanese population.
17852867
2007
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
Single nucleotide polymorphisms in the promoter region of the E-cadherin gene in gastric cancer: case-control study in a young Mexican population.
17549573
2007
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population.
18482459
2008
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
Biomarker
group
LHGDN
Association of extracellular cleavage of E-cadherin mediated by MMP-7 with HGF-induced in vitro invasion in human stomach cancer cells.
17396032
2007
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
E-cadherin and hereditary diffuse gastric cancer.
17981184
2007
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
Germline E-cadherin mutations in familial lobular breast cancer.
17660459
2007
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family.
17126523
2007
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
0.600
GeneticVariation
group
LHGDN
Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer.
12444556
2002