Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Therapeutic disease CTD_human Changes in adrenocorticotropic hormone (ACTH) and cortisol levels in drug addicts treated by a new and rapid detoxification procedure using acupuncture and naloxone. 225122 1979
Entrez Id: 3061
Gene Symbol: HCRTR1
HCRTR1 		0.310 Biomarker disease CTD_human Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats. 20667500 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.310 Biomarker disease CTD_human The DRD2 TaqI-B polymorphism and its relationship to smoking abstinence and withdrawal symptoms. 17189962 2007
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Biomarker disease CTD_human Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene. 15689546 2005
Entrez Id: 3061
Gene Symbol: HCRTR1
HCRTR1 		0.310 Biomarker disease BEFREE Antagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus. 28583577 2017
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Biomarker disease CTD_human Changes in adrenocorticotropic hormone (ACTH) and cortisol levels in drug addicts treated by a new and rapid detoxification procedure using acupuncture and naloxone. 225122 1979
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Biomarker disease CTD_human Withdrawal following sufentanil/propofol and sufentanil/midazolam. Sedation in surgical ICU patients: correlation with central nervous parameters and endogenous opioids. 15714323 2005
Entrez Id: 3060
Gene Symbol: HCRT
HCRT 		0.310 Biomarker disease BEFREE Antagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus. 28583577 2017
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Therapeutic disease CTD_human Circadian alteration in neurobiology during protracted opiate withdrawal in rats. 20738730 2010
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Therapeutic disease CTD_human Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene. 15689546 2005
Entrez Id: 3060
Gene Symbol: HCRT
HCRT 		0.310 Biomarker disease CTD_human Circadian alteration in neurobiology during protracted opiate withdrawal in rats. 20738730 2010
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Biomarker disease BEFREE The current study examined whether exogenous β-EP, delivered using an adenoviral vector into the CNS could attenuate morphine withdrawal syndrome in rats. 21983207 2011
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Biomarker disease CTD_human Circadian alteration in neurobiology during protracted opiate withdrawal in rats. 20738730 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.310 GeneticVariation disease BEFREE Influence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction. 23238469 2012
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Therapeutic disease CTD_human Withdrawal following sufentanil/propofol and sufentanil/midazolam. Sedation in surgical ICU patients: correlation with central nervous parameters and endogenous opioids. 15714323 2005
Entrez Id: 4887
Gene Symbol: NPY2R
NPY2R 		0.300 Biomarker disease CTD_human Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. 18828811 2008
Entrez Id: 2166
Gene Symbol: FAAH
FAAH 		0.300 Biomarker disease CTD_human Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. 19002671 2009
Entrez Id: 8973
Gene Symbol: CHRNA6
CHRNA6 		0.300 Biomarker disease CTD_human The role of alpha6-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal. 19644040 2009
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2 		0.300 Therapeutic disease CTD_human Immune response products alter CNS activity: interferon modulates central opioid functions. 2449543 1988
Entrez Id: 1385
Gene Symbol: CREB1
CREB1 		0.300 Biomarker disease CTD_human Evidence for beta1-adrenergic receptor involvement in amygdalar corticotropin-releasing factor gene expression: implications for cocaine withdrawal. 18596687 2009
Entrez Id: 1141
Gene Symbol: CHRNB2
CHRNB2 		0.300 Biomarker disease CTD_human Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs. 18184829 2008
Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A 		0.300 Biomarker disease CTD_human Enhanced morphine withdrawal and micro -opioid receptor G-protein coupling in A2A adenosine receptor knockout mice. 14756803 2004
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.300 Biomarker disease CTD_human Neurobehavioral syndrome induced by H2-receptor blocker withdrawal: possible role of prolactin. 9037573 1997
Entrez Id: 387
Gene Symbol: RHOA
RHOA 		0.300 Biomarker disease CTD_human E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking. 30158054 2018
Entrez Id: 2353
Gene Symbol: FOS
FOS 		0.300 Biomarker disease CTD_human Anxiety-like symptoms induced by morphine withdrawal may be due to the sensitization of the dorsal periaqueductal grey. 18485423 2008