Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7033
Gene Symbol: TFF3
TFF3 		0.010 Biomarker disease BEFREE Trefoil factor 3 (TFF3) was recently reported to modulate withdrawal syndrome of morphine, but the effects of TFF3 on the cocaine-induced behavioral changes are still elusive. 27282818 2016
Entrez Id: 367
Gene Symbol: AR
AR 		0.070 GeneticVariation disease BEFREE A direct association between AR mutations and endocrine withdrawal syndrome has been investigated in only one study thus far. 12083956 2001
Entrez Id: 2353
Gene Symbol: FOS
FOS 		0.300 Biomarker disease CTD_human A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase. 15196791 2004
Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C 		0.300 Biomarker disease CTD_human A potent serotonin-modulating compound AP-267 attenuates morphine withdrawal-induced blood-brain barrier dysfunction in rats. 17105947 2006
Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A 		0.300 Biomarker disease CTD_human Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice. 16470403 2006
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1 		0.300 Biomarker disease CTD_human Activation of the ERK signalling pathway contributes to the adaptive changes in rat hearts during naloxone-induced morphine withdrawal. 17549049 2007
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3 		0.300 Biomarker disease CTD_human Activation of the ERK signalling pathway contributes to the adaptive changes in rat hearts during naloxone-induced morphine withdrawal. 17549049 2007
Entrez Id: 64132
Gene Symbol: XYLT2
XYLT2 		0.010 Biomarker disease BEFREE Analgosedation and withdrawal syndrome development were monitored using COMFORT-neo/-B scores and SOS score. 28006928 2016
Entrez Id: 3060
Gene Symbol: HCRT
HCRT 		0.310 Biomarker disease BEFREE Antagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus. 28583577 2017
Entrez Id: 3061
Gene Symbol: HCRTR1
HCRTR1 		0.310 Biomarker disease CTD_human Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats. 20667500 2010
Entrez Id: 3061
Gene Symbol: HCRTR1
HCRTR1 		0.310 Biomarker disease BEFREE Antagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus. 28583577 2017
Entrez Id: 367
Gene Symbol: AR
AR 		0.070 GeneticVariation disease BEFREE Antiandrogen withdrawal syndrome and alternative antiandrogen therapy associated with the W741C mutant androgen receptor in a novel prostate cancer xenograft. 19790238 2010
Entrez Id: 2353
Gene Symbol: FOS
FOS 		0.300 Biomarker disease CTD_human Anxiety-like symptoms induced by morphine withdrawal may be due to the sensitization of the dorsal periaqueductal grey. 18485423 2008
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4 		0.010 Biomarker disease BEFREE Because ARA70-N2 containing the AR-interacting FXXLF motif without coactivation function can suppress HF-enhanced AR transactivation in the hormone-refractory LNCaP cells, using the ARA70-N2 inhibitory peptide at the hormone refractory stage to battle the HF withdrawal syndrome may become an alternative strategy to treat prostate cancer. 15166229 2004
Entrez Id: 354
Gene Symbol: KLK3
KLK3 		0.030 AlteredExpression disease BEFREE Bicalutamide was withdrawn in anticipation of anti-androgen withdrawal syndrome and the PSA level declined temporally. 29434990 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP 		0.300 Biomarker disease CTD_human C-reactive protein and depressed mood in a sub-group of smokers during nicotine abstinence. 12858318 2003
Entrez Id: 114
Gene Symbol: ADCY8
ADCY8 		0.300 Biomarker disease CTD_human Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. 16914643 2006
Entrez Id: 107
Gene Symbol: ADCY1
ADCY1 		0.300 Biomarker disease CTD_human Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. 16914643 2006
Entrez Id: 354
Gene Symbol: KLK3
KLK3 		0.030 GeneticVariation disease BEFREE Cessation of flutamide for at least 4 weeks and, in the case of bicalutamide, even 8 weeks, is mandatory before antiandrogen withdrawal syndrome can be excluded as the cause of decreasing PSA values. 11085345 2000
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Therapeutic disease CTD_human Changes in adrenocorticotropic hormone (ACTH) and cortisol levels in drug addicts treated by a new and rapid detoxification procedure using acupuncture and naloxone. 225122 1979
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Biomarker disease CTD_human Changes in adrenocorticotropic hormone (ACTH) and cortisol levels in drug addicts treated by a new and rapid detoxification procedure using acupuncture and naloxone. 225122 1979
Entrez Id: 2775
Gene Symbol: GNAO1
GNAO1 		0.300 Biomarker disease CTD_human Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats. 12199159 2002
Entrez Id: 2770
Gene Symbol: GNAI1
GNAI1 		0.300 Biomarker disease CTD_human Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats. 12199159 2002
Entrez Id: 2778
Gene Symbol: GNAS
GNAS 		0.300 Biomarker disease CTD_human Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats. 12199159 2002
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Therapeutic disease CTD_human Circadian alteration in neurobiology during protracted opiate withdrawal in rats. 20738730 2010