Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.100 AlteredExpression disease LHGDN GCA patients with ischemic complications have lower tissue expression and circulating levels of IL-6 than patients with no ischemic events. 12742994 2003
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.100 GeneticVariation disease BEFREE GCA incidence (n = 17 countries) was associated with population HLA-DRB1*04 allele frequency (P = 0.008; adjusted R(2) = 0.51 on univariable analysis, adjusted R(2) = 0.62 after also including latitude); latitude also made an independent contribution. 26223536 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.100 GeneticVariation disease BEFREE GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). 28277489 2017
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1 		0.040 GeneticVariation disease BEFREE GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). 28277489 2017
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.010 GeneticVariation disease BEFREE Polymyalgia rheumatica development in a patient under PI3K inhibitor therapy for chronic lymphocytic leukaemia. 29122897 2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB 		0.010 GeneticVariation disease BEFREE Polymyalgia rheumatica development in a patient under PI3K inhibitor therapy for chronic lymphocytic leukaemia. 29122897 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.010 GeneticVariation disease BEFREE Polymyalgia rheumatica development in a patient under PI3K inhibitor therapy for chronic lymphocytic leukaemia. 29122897 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG 		0.010 GeneticVariation disease BEFREE Polymyalgia rheumatica development in a patient under PI3K inhibitor therapy for chronic lymphocytic leukaemia. 29122897 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.050 Biomarker disease BEFREE GCA CD (cluster of differentiation) 4<sup>+</sup> T cells required MMP-9-producing monocytes to penetrate through matrix built from type IV collagen. 29970365 2018
Entrez Id: 2006
Gene Symbol: ELN
ELN 		0.010 GeneticVariation disease BEFREE Giant cell arteritis appears to localize in elastin-containing arteries and can cause similar myalgias. 4001042 1985
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.100 GeneticVariation disease BEFREE GCA seems to be associated with HLA DRB1*04 (regardless of the subtype) and this association appears to be accompanied by corticosteroid resistance, suggesting that genomic typing may be useful to identify patients eligible for early alternative treatment to corticosteroid drugs. 9771216 1998
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.100 GeneticVariation disease BEFREE HLA-DRB1 alleles associated with polymyalgia rheumatica in northern Italy: correlation with disease severity. 10225816 1999
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.100 GeneticVariation disease BEFREE HLA-DRB1, DQA1, and DQB1 alleles associated with giant cell arteritis in northern Italy. 10555899 1999
Entrez Id: 6352
Gene Symbol: CCL5
CCL5 		0.040 GeneticVariation disease BEFREE RANTES gene polymorphism in polymyalgia rheumatica, giant cell arteritis and rheumatoid arthritis. 10895380 2000
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.100 GeneticVariation disease BEFREE DRB1 alleles in polymyalgia rheumatica and rheumatoid arthritis in southern France. 11251689 2001
Entrez Id: 129831
Gene Symbol: RBM45
RBM45 		0.080 GeneticVariation disease BEFREE DRB1 alleles in polymyalgia rheumatica and rheumatoid arthritis in southern France. 11251689 2001
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		0.050 Biomarker disease BEFREE Estrogen receptor alpha (ER alpha) accumulates in the cytoplasm of smooth muscle cells, activated mononuclear inflammatory cells and giant cells in the temporal arteries of GCA patients, as well as in smooth muscle cells in arteries from non-GCA controls. 11407083 2001
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1 		0.060 GeneticVariation disease BEFREE Intercellular adhesion molecule-1 gene polymorphisms in isolated polymyalgia rheumatica. 11911111 2002
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.100 GeneticVariation disease BEFREE IL-6-174 allele C was marginally increased infrequency in GCA patients with PMR manifestations compared with isolated GCA (Pcorr 0.06; OR = 2.3). 12051396 2003
Entrez Id: 50639
Gene Symbol: MBL3P
MBL3P 		0.010 GeneticVariation disease BEFREE MBL and HLA-DRB1 alleles were determined by polymerase chain reaction in 102 Danish patients with PMR (n = 37) or GCA (n = 65). 12375325 2002
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.100 Biomarker disease BEFREE HLA-DRB1*04 was found in 47% of patients with PMR only and in 54% of patients with GCA, which differed significantly from the 35% found in controls (p = 0.01). 12375325 2002
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		0.050 GeneticVariation disease BEFREE MMP2 genotypes were determined by PCR-based denaturing high-performance liquid chromatography analysis and direct DNA sequencing in 356 patients with GCA and 789 frequency-matched controls in an ethnic Chinese population. 12873995 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.030 GeneticVariation disease BEFREE Endothelial nitric oxide synthase haplotype associations in biopsy-proven giant cell arteritis. 12966609 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.020 GeneticVariation disease BEFREE Vascular endothelial growth factor gene polymorphisms in giant cell arteritis. 14528511 2003
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.100 GeneticVariation disease LHGDN DRB1*04 (OR, 1.9 [0.96 to 3.8]; P =.06), especially *0401 (OR, 2.8 [1 to 7.7]; P =.04), and DRB1*07 (OR, 2.3 [1.2 to 4.6]; P =.01) were more frequent in GCA than in PMR. 15305244 2004