Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.130 GeneticVariation disease BEFREE Histologic and molecular findings of botryoid-type embryonal rhabdomyosarcoma (bERMS) and thyroid nodules from a 12-year-old DICER1 mutation carrier (p.Arg1060Ilefs*7) were investigated, providing interesting clues for understanding thyroid carcinogenesis. 29538609 2018
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.130 Biomarker disease BEFREE DICER1 is a driver of pediatric thyroid nodules, and DICER1-mutated PTC may represent a distinct class of low-risk malignancies. 29474644 2018
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.130 GeneticVariation disease BEFREE Somatic DICER1 RNase IIIb missense mutations were identified in thyroid nodules from three of the four siblings. 26555935 2016
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.130 Biomarker disease HPO
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.120 GeneticVariation disease BEFREE We searched for germline mutations in PTEN in a 49-year-old female patient who presented trichilemmoma with previous history of breast carcinoma, and thyroidectomy for a thyroid nodule. 23295304 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.120 GeneticVariation disease BEFREE In parents and siblings, PTEN test results were negative for mutations.Endocrine evaluation revealed an abnormal thyroid nodule on ultrasound. 20814261 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.120 CausalMutation disease CLINVAR
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.100 GeneticVariation disease BEFREE Seventeen patients underwent a thyroid nodule FNAB (results: 12 benign, one follicular neoplasm, three suspicious for malignancy, and one papillary thyroid cancer [PTC]), from which six underwent thyroidectomy; PTC was confirmed by surgical pathology for all cases (8.5% of all nodules observed). 31461359 2020
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.100 GeneticVariation disease BEFREE Seventeen patients underwent a thyroid nodule FNAB (results: 12 benign, one follicular neoplasm, three suspicious for malignancy, and one papillary thyroid cancer [PTC]), from which six underwent thyroidectomy; PTC was confirmed by surgical pathology for all cases (8.5% of all nodules observed). 31461359 2020
Entrez Id: 5979
Gene Symbol: RET
RET
0.100 GeneticVariation disease BEFREE Seventeen patients underwent a thyroid nodule FNAB (results: 12 benign, one follicular neoplasm, three suspicious for malignancy, and one papillary thyroid cancer [PTC]), from which six underwent thyroidectomy; PTC was confirmed by surgical pathology for all cases (8.5% of all nodules observed). 31461359 2020
Entrez Id: 5726
Gene Symbol: TAS2R38
TAS2R38
0.100 GeneticVariation disease BEFREE Seventeen patients underwent a thyroid nodule FNAB (results: 12 benign, one follicular neoplasm, three suspicious for malignancy, and one papillary thyroid cancer [PTC]), from which six underwent thyroidectomy; PTC was confirmed by surgical pathology for all cases (8.5% of all nodules observed). 31461359 2020
Entrez Id: 2158
Gene Symbol: F9
F9
0.100 GeneticVariation disease BEFREE Seventeen patients underwent a thyroid nodule FNAB (results: 12 benign, one follicular neoplasm, three suspicious for malignancy, and one papillary thyroid cancer [PTC]), from which six underwent thyroidectomy; PTC was confirmed by surgical pathology for all cases (8.5% of all nodules observed). 31461359 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker disease BEFREE BRAF prevalence among thyroid nodules with FNA read as SFM according to the most popular classification systems (i.e., Bethesda V, Thy4, TIR4 category) was searched.The random-effects model was used. 31811566 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation disease BEFREE ROC of the subject was constructed to evaluate the diagnostic value of these 2 methods and their combination.BRAF mutation in FNAC of thyroid nodules occurred in 2796 samples (57.35%). 31305422 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 AlteredExpression disease BEFREE Participants were further stratified into thyroid autoantibody positive group (at least one positive) and thyroid autoantibody negative group (both negative) according to the thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) levels, and restricted cubic spline regression was also applied to determine the possible nonlinear relationship between urinary BPA and TNs. 30825751 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 AlteredExpression disease BEFREE We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules. 29890543 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation disease BEFREE We aimed to investigate the diagnostic value of the BRAF mutation in cytologically indeterminate thyroid nodules after the reclassification of a variant thyroid carcinoma. 30863114 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE We aimed to evaluate the effects of Tg on the function of Tregs in patients with thyroid nodules. 30822273 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation disease BEFREE BRAF mutation analysis by ARMS-PCR refines thyroid nodule management. 31441082 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Thyroglobulin, age, pre-pregnancy body mass index, and iodine-excessive region were associated with TNs (odds ratio = 1.01, 1.06, 1.04, and 2.38, respectively). 30979661 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 AlteredExpression disease BEFREE We successfully established and validated a simple and reliable preoperative prediction model for FTC using the preoperative thyroglobulin level and ultrasonographic features of the thyroid nodules. 31050007 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation disease BEFREE The aim of this study was to estimate the diagnostic value of BRAF V600E mutation status combined with cytomorphological features for diagnosis of papillary thyroid cancer (PTC) in cytologically indeterminate thyroid nodules. 29566402 2019
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 Biomarker disease BEFREE When they arrived at our center for both the presence of thyroid nodules and elevated serum calcitonin values, the MTC was already metastatic, and the older patient had already developed a bilateral PHEO. 30597074 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation disease BEFREE TERT promoter and BRAF mutations were detected in 20/436 (4.6%) and 257/434 thyroid nodules (59.2%), respectively. 31042674 2019
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 GeneticVariation disease BEFREE We used pyrosequencing and quantitative real-time PCR (qRT-PCT) approaches to examine BRAF<sup>V600E</sup> mutation and TMPRSS4 mRNA level in FNAB specimens of thyroid nodules. 30518486 2018