HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The allele and haplotype frequencies of HLA-A, B and DRB1 were determined and compared between patients with MDR/RR-TB and patients with drug-susceptible PTB.
|
29219243 |
2018 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, the interaction between alcohol and HLA-DRB1*04:11:01 increased the risk for developing pulmonary TB (p = 0.0001; OR = 51.3; 95% CI = 6.81 to 386).
|
26901036 |
2016 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found association of three variants in the region harboring genes encoding the class II human leukocyte antigens (HLAs): rs557011[T] (minor allele frequency (MAF) = 40.2%), associated with M. tuberculosis infection (odds ratio (OR) = 1.14, P = 3.1 × 10(-13)) and PTB (OR = 1.25, P = 5.8 × 10(-12)), and rs9271378[G] (MAF = 32.5%), associated with PTB (OR = 0.78, P = 2.5 × 10(-12))--both located between HLA-DQA1 and HLA-DRB1--and a missense variant encoding rs9272785;rs386699558" genes_norm="3117">p.Ala210Thr in HLA-DQA1 (MAF = 19.1%, rs9272785), associated with M. tuberculosis infection (P = 9.3 × 10(-9), OR = 1.14).
|
26829749 |
2016 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conversely, the presence of the genes HLA-DRB1*07:01 (OR 0.74, CI 0.56-0.97), HLA-DQB1*03:01 (OR 0.77, CI 0.61-0.97), HLA-DQB1*04:02 (OR 0.57, CI 0.39-0.83), HLA-DQA1*04:01 (OR 0.50, CI 0.26-0.95) and HLA-DQA1*05:01 (OR 0.66, CI 0.48-0.92) demonstrated protection against PTB.
|
27412154 |
2016 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between other HLA-DRB1 family alleles and specific alleles and predisposition to PTB was not statistically significant.
|
26056112 |
2015 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the comparison of TAP2 gene with the DRB1*08:03, which is associated with TAP2*Bky2 and PTB in Koreans, we demonstrated the hierarchy of these association factors.
|
25846714 |
2015 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, HLA-A(∗)24-B(∗)40-DRB1(∗)15 haplotype was found to be specific to Sahariya tribe with a strong predisposition to PTB.
|
23994122 |
2014 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-A and HLA-DRB1 amino acid polymorphisms are associated with susceptibility and protection to pulmonary tuberculosis in a Greek population.
|
22504415 |
2012 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DRB1 promoter region sequences had no association with the development of pulmonary tuberculosis.
|
21751159 |
2011 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, HLA-DRB1*1202 in the absence of HLA-B*1802 showed a significant association with resistance to recurrent PTB (p = 8.2 x 10(-4), odds ratio = 0.32, 95% confidence interval = 0.16-0.64), suggesting that stronger susceptibility effect of HLA-B*1802 masked the protective effect of HLA-DRB1*1202.
|
20438789 |
2010 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis of HLA-A, -B antigens and -DRB1 alleles in south Indian HIV-1-infected patients with and without pulmonary tuberculosis.
|
19392836 |
2009 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, the haplotypes HLA-DRB1*1502-DPB1*0201 and HLA-DQB1*0601-DPB1*0201 (Pc < 0.001) and HLA-DRB1*1502-DQB1*0601-DPB1*0201 (p = 0.006, OR 5.09, 95% CI 1.42-22.66) were significantly overrepresented in HIV+PTB+ patients compared to healthy controls suggesting that genetic susceptibility to PTB development in HIV patients may be modulated by interplay between HLA class II alleles, besides HLA class I alleles.
|
18652916 |
2008 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The DRB1*04 allele is associated with susceptibility to pulmonary tuberculosis, whereas DRB1*11 is associated with protection from pulmonary tuberculosis in the Syrian population.
|
18998014 |
2008 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the regulatory role of HLA-DRB1 alleles on cytokine response to live M. tuberculosis and its culture filtrate antigen (CFA) in normal healthy subjects (NHS) and pulmonary tuberculosis (PTB) patients.
|
17826339 |
2007 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 typing was done in normal healthy subjects (NHS: n = 156) and patients with pulmonary tuberculosis (PTB: n = 102) by polymerase chain reaction-based sequence-specific oligonucleotide hybridization method.
|
17845310 |
2007 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomic DNA from 95 patients with pulmonary tuberculosis (PTB) and 117 ethnically matched, healthy controls were typed for HLA-DRB1, DRB3, DRB4, DRB5, DQB1, and VDR polymorphisms FokI, BsmI, ApaI, and TaqI using polymerase chain reaction-sequence specific primers (PCR-SSP).
|
16916662 |
2006 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association of HLA-DRB, DQA1, DQB1 alleles and haplotype frequency in Iranian patients with pulmonary tuberculosis.
|
15305487 |
2004 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA DRB1 homozygosity among HIV-positive subjects was associated with reduced risk of developing pulmonary TB but increased risk of rapid progression to pleural effusion TB.
|
14999612 |
2004 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA DRB1*02 and its subtypes predispose individuals for a far-advanced sputum-positive pulmonary tuberculosis transcending ethnic boundaries.
|
11500439 |
2001 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1 *1501 and *1502 positive as well as negative ATB patients showed a higher antibody titre as compared to controls and ITB patients.
|
11558319 |
2001 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Results suggest that the presence of HLA-DRB1*16 alleles may increase the risk of development of PTB, whereas HLA-DRB1*13 alleles may be resistant to tuberculosis.
|
11179915 |
2000 |
HLA-DRB1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The frequencies of alleles DQA1*0101 (odds ratio [OR], 6.18; 95% confidence interval [CI], 2.38 to 16.08), DQB1*0501 (OR, 6.16; 95% CI, 2.44 to 17.71), and DRB1*1501 (OR, 7.92; 95% CI, 2.71 to 23.14) were significantly increased in nonimmunosuppressed patients with PTB when compared with healthy subjects.
|
10027443 |
1999 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*1501 and DQB1*0601 predisposed to sputum positive pulmonary tuberculosis, and DPB1*04 was preventive and epistatic to this risk.
|
10707259 |
1999 |