Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 842
Gene Symbol: CASP9
CASP9
0.200 Therapeutic disease RGD Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. 29138829 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.200 Therapeutic disease RGD Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. 29138829 2018
Entrez Id: 3549
Gene Symbol: IHH
IHH
0.200 Biomarker disease RGD Indian hedgehog in synovial fluid is a novel marker for early cartilage lesions in human knee joint. 24786088 2014
Entrez Id: 177
Gene Symbol: AGER
AGER
0.200 Therapeutic disease RGD Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. 23894457 2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.200 Therapeutic disease RGD Duhuo Jisheng Decoction promotes chondrocyte proliferation through accelerated G1/S transition in osteoarthritis. 24009074 2013
Entrez Id: 11096
Gene Symbol: ADAMTS5
ADAMTS5
0.200 Therapeutic disease RGD Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis. 23546441 2013
Entrez Id: 4322
Gene Symbol: MMP13
MMP13
0.200 Therapeutic disease RGD Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes. 22890185 2012
Entrez Id: 176
Gene Symbol: ACAN
ACAN
0.200 Therapeutic disease RGD Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model. 21853458 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.200 Therapeutic disease RGD Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes. 22890185 2012
Entrez Id: 5175
Gene Symbol: PECAM1
PECAM1
0.200 Biomarker disease RGD Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. 21864409 2011
Entrez Id: 222236
Gene Symbol: NAPEPLD
NAPEPLD
0.200 Biomarker disease RGD Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. 20722027 2010
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
0.200 Biomarker disease RGD Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage. 20434574 2010
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.200 Therapeutic disease RGD [Preventive and therapeutic effects of Yiqi Huayu Recipe on degeneration of articular cartilage in rats with osteoarthritis]. 19216861 2009
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
0.200 Biomarker disease MGD TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. 18704116 2008
Entrez Id: 8200
Gene Symbol: GDF5
GDF5
0.200 Biomarker disease MGD A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice. 17656374 2007
Entrez Id: 11096
Gene Symbol: ADAMTS5
ADAMTS5
0.200 Biomarker disease RGD Global analyses of gene expression in early experimental osteoarthritis. 17530714 2007
Entrez Id: 4322
Gene Symbol: MMP13
MMP13
0.200 Biomarker disease RGD Global analyses of gene expression in early experimental osteoarthritis. 17530714 2007
Entrez Id: 4148
Gene Symbol: MATN3
MATN3
0.200 Biomarker disease MGD Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis. 16877353 2006
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.200 Biomarker disease RGD Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis. 16508959 2006
Entrez Id: 538
Gene Symbol: ATP7A
ATP7A
0.200 Biomarker disease MGD Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress. 16371425 2006
Entrez Id: 54206
Gene Symbol: ERRFI1
ERRFI1
0.200 Biomarker disease MGD Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. 16087873 2005
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.200 Biomarker disease RGD TRAIL induces apoptosis of chondrocytes and influences the pathogenesis of experimentally induced rat osteoarthritis. 14872496 2004
Entrez Id: 8797
Gene Symbol: TNFRSF10A
TNFRSF10A
0.200 Biomarker disease RGD TRAIL induces apoptosis of chondrocytes and influences the pathogenesis of experimentally induced rat osteoarthritis. 14872496 2004
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
0.200 Biomarker disease MGD Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. 14617750 2003
Entrez Id: 1301
Gene Symbol: COL11A1
COL11A1
0.200 Biomarker disease MGD Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho). 13130470 2003