Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression. 8220113 1993
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Inhibition of apoptosis through bcl-2 protein expression appears to be specifically associated with promotion of intestinal-type gastric adenocarcinoma but does not appear to be active and/or correlated with tumor progression. 7712429 1995
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE Abnormal bcl-2 immunoreactivity in 1), the earliest precursor dysplastic lesions and its persistence throughout neoplastic progression and 2), contiguous morphologically unaltered nondysplastic epithelium suggests that bcl-2 alterations occur early during the morphological and molecular sequence of events leading to gastrointestinal epithelial neoplasia. 7856728 1995
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE We conclude from our results that bcl-2 protein is expressed by benign and malignant melanocytic tumors of the skin, but there is loss of bcl-2 protein expression with increasing tumor progression. 7777475 1995
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE We conclude that, in contrast to its role in gastric neoplasia, bcl-2 alterations are not an important molecular marker in the neoplastic progression of Barrett's mucosa. 8552577 1996
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE This suggests the possibility that alterations in p53 followed by over-expression of bcl-2 occur early in oral carcinogenesis resulting in defective apoptosis and subsequent tumor progression. 8697436 1996
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 Biomarker phenotype BEFREE The bcl-2 immunostaining pattern could be subdivided into two groups, basal type and diffuse type, with the incidence of the latter being clearly increased, in line with tumor progression. 8635035 1996
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE The frequency of apoptosis in colorectal neoplasia appears to increase in the course of tumor progression in association with a decline in bcl-2 expression, but is not influenced by p53 gene mutations. 9143411 1997
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE These data suggest that, in endometrial carcinomas, Bcl-2 and p53 alterations may play important roles in determining whether tumor progression from early to advanced stages will occur. 9292705 1997
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Protein expression of BCL-2 in prostate cancer is highly correlated with cancer progression and androgen-independent phenotype. 9090501 1997
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Toward this aim, we analyzed, using immunohistochemistry, the expression of the p53 gene and of its transcriptional target genes bax, bcl2, and waf1 in preinvasive bronchial lesions from 69 patients with lung cancer and in similar lesions from 20 patients with no cancer progression. p53 accumulation occurred with increasing frequency, from 19% in mild dysplasia to 36% in moderate dysplasia and 59% in carcinoma in situ, and was exclusively observed in patients with p53-positive carcinoma. 9676834 1998
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Expression of bcl-2 is lost during tumor progression and is a strong prognostic parameter, suggesting that the regulation of apoptosis plays an important role in the behavior of cervical carcinomas. 9465813 1998
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Expression of bcl-2 in testicular carcinoma: correlation with tumor progression and MDR1/Pgp. 9669816 1998
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 Biomarker phenotype BEFREE Interaction between p53, Bcl-2, and other products of tumor suppressor genes or oncogenes are probably critical in tumor progression and response to treatment. 10494513 1999
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Altered expression of Bcl-2 family proteins has been associated with tumorigenesis and tumor progression as well as resistance to radiotherapy and chemotherapy. 10547558 1999
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model. 10597263 2000
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE Typically, 1q21-23 rearrangements arise during tumor evolution and accompany disease-specific chromosomal rearrangements such as t(14;18) (BCL2) and t(8;14) (MYC), where they are thus thought to play an important role in tumor progression. 10618414 2000
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE In the present study, we investigated the effect of bcl-2 over-expression on the activity of the transcription factor NF-kappaB, an important regulator of genes involved in tumor progression and invasion. 10738245 2000
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 Biomarker phenotype BEFREE These results indicate that Bcl-2 inhibits tumor progression in the liver, possibly by interfering with hepatocyte proliferation. 11212255 2001
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor. 12170763 2002
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 Biomarker phenotype BEFREE Bcl-2 and Bcl-X(L) may play a critical role in cancer progression. 14613034 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 Biomarker phenotype BEFREE Overexpression of the anti-apoptotic proteins bcl-2 and bcl-xL is implicated in breast cancer development, tumor progression and drug resistance. 12452453 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 Biomarker phenotype BEFREE Previous studies further suggest that such phospho-Bcl-2 regulation may influence tumor progression in colorectal and other cancers; however, phosphorylation status of the Ser70 of Bcl-2 (pSer70) in vivo in tumors remains obscure. 16243795 2006
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Expression of the proto-oncogene Bcl-2 is associated with tumor progression. 17237270 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 Biomarker phenotype BEFREE These data indicate that the survival requirements for tumor-susceptible PC(pre) and PCs are distinct and that tumor progression likely develops as PC(pre) transition to functional PCs when apoptotic pathways such as members of the Bcl-2 family are disabled. 19017943 2008