Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1314
Gene Symbol: COPA
COPA
0.300 Biomarker disease CTD_human COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. 25894502 2015
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
0.300 Biomarker disease CTD_human Manganese superoxide dismutase and catalase are coordinately expressed in the alveolar region in chronic interstitial pneumonias and granulomatous diseases of the lung. 10673208 2000
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.170 Biomarker disease BEFREE These results demonstrate that synoviolin is involved in the onset of interstitial pneumonia induced by exon 4-deleted SP-C, which suggests that synoviolin inhibitors may be used in the treatment of the disease. 25351210 2015
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.170 GeneticVariation disease BEFREE Familial interstitial pneumonia in an adolescent boy with surfactant protein C gene (Y104H) mutation. 24003539 2013
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.170 GeneticVariation disease BEFREE In individuals with familial interstitial pneumonia without SFTPC mutations and patients with sporadic IPF, we also found UPR activation selectively in AECs lining areas of fibrotic remodeling. 18390830 2008
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.170 GeneticVariation disease BEFREE Interstitial pneumonias have recently been associated with mutations in the gene encoding surfactant protein C (SFTPC). 17005585 2007
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.170 Biomarker disease BEFREE Clinical features and genetic analysis of surfactant protein C in adult-onset familial interstitial pneumonia. 16423270 2006
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.170 GeneticVariation disease BEFREE Adding to the importance of a detailed understanding of SP-C biosynthesis has been the recent association of mutations in the proSP-C sequence with chronic interstitial pneumonias in children and adults. 15709974 2005
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.170 GeneticVariation disease BEFREE Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. 11991887 2002
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.170 Biomarker disease HPO
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.100 Biomarker disease HPO
Entrez Id: 5896
Gene Symbol: RAG1
RAG1
0.100 Biomarker disease HPO
Entrez Id: 26277
Gene Symbol: TINF2
TINF2
0.100 Biomarker disease HPO
Entrez Id: 7012
Gene Symbol: TERC
TERC
0.100 Biomarker disease HPO
Entrez Id: 5336
Gene Symbol: PLCG2
PLCG2
0.100 Biomarker disease HPO
Entrez Id: 727897
Gene Symbol: MUC5B
MUC5B
0.030 GeneticVariation disease BEFREE We investigated predisposition of the MUC5B polymorphism to fibrotic interstitial pneumonias in Dutch Caucasian patient cohorts. 26699835 2016
Entrez Id: 727897
Gene Symbol: MUC5B
MUC5B
0.030 GeneticVariation disease BEFREE The pulmonary fibrosis-associated MUC5B promoter polymorphism does not influence the development of interstitial pneumonia in systemic sclerosis. 22576636 2013
Entrez Id: 727897
Gene Symbol: MUC5B
MUC5B
0.030 GeneticVariation disease BEFREE A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis. 21506741 2011
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.020 Biomarker disease BEFREE TLR9 in fibroblasts appeared to be increased by profibrotic Th2 cytokines (IL-4 and IL-13) and this was true in fibroblasts cultured from the most severe form of IIP, idiopathic pulmonary fibrosis (IPF) SLBs, in non-specific interstitial pneumonia fibroblast lines, and in normal fibroblasts. 18633634 2008
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.020 Biomarker disease BEFREE The patient finally had a partial clinical response (reduction in fever and irritability) and complete laboratory response (improved C-reactive protein and serum amyloid A levels) to humanized anti-IL-6 receptor antibody (MRA), but died from congestive heart failure and interstitial pneumonia 2 months after initiation of therapy. 16802372 2006
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.020 Biomarker disease BEFREE Molecular and immunohistochemical analysis of IL-4, interferon gamma (IFNgamma), IL-13, IL-4 receptor (IL-R), and IL-13 receptor subunits in surgical lung biopsies (SLBs) from 39 patients (21 usual interstitial pneumonia (UIP), six non-specific interstitial pneumonia (NSIP), eight respiratory bronchiolitic interstitial lung disease (RBILD), and five normal controls). 15113854 2004
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.020 Biomarker disease BEFREE Molecular and immunohistochemical analysis of IL-4, interferon gamma (IFNgamma), IL-13, IL-4 receptor (IL-R), and IL-13 receptor subunits in surgical lung biopsies (SLBs) from 39 patients (21 usual interstitial pneumonia (UIP), six non-specific interstitial pneumonia (NSIP), eight respiratory bronchiolitic interstitial lung disease (RBILD), and five normal controls). 15113854 2004
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.020 AlteredExpression disease BEFREE IFN-gamma mRNA was detected in BALF T cells in corticosteroid-resistant and corticosteroid-sensitive IP but not in controls without IP, whereas IL-4 mRNA was virtually undetected in BALF T cells in both the IP groups. 12197897 2002
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.020 GeneticVariation disease BEFREE As for cytokine network, prolonged overexpression of TNF-alpha along with increasing interleukin 6 (IL-6) were associated with the progression of interstitial pneumonitis. 9512902 1998
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.010 GeneticVariation disease BEFREE Rare variants in RTEL1 are associated with familial interstitial pneumonia. 25607374 2015