Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE These data from a Chinese cohort provide further genetic evidence suggesting that dysregulated PI3K/Akt pathway plays a significant role in the pathogenesis of thyroid tumors, particularly FTC. 17426084 2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 GeneticVariation disease BEFREE Single nucleotide polymorphism (SNP) rs17849071 was recently reported to be inversely associated with PIK3CA amplification in follicular thyroid cancer, but the main function of this SNP remains unclear. 24908061 2014
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 GeneticVariation disease BEFREE Thus, the present study uncovers an interesting phenomenon that rs17849071G/T is protective against FTC possibly through preventing PIK3CA amplifications. 23185308 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 GeneticVariation disease BEFREE It is proposed that genetic alterations in the PI3K/Akt pathway promote thyroid cell transformation to FTC and that genetic alterations in the MAPK pathway promote cell transformation to PTC; accumulation of multiple genetic alterations that can activate both pathways promotes thyroid cancer aggressiveness and progression to ATC. 20578891 2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Genetic alterations in the RTKs and PI3K/Akt and MAPK pathways are extremely prevalent in ATC and FTC, providing a strong genetic basis for an extensive role of these signaling pathways and the development of therapies targeting these pathways for ATC and FTC, particularly the former. 18492751 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE ST6GalNAcII mediates tumor invasion through PI3K/Akt/NF-κB signaling pathway in follicular thyroid carcinoma. 26820593 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Altogether, our findings provide insight into the role of SOSTDC1 as a novel functional tumor suppressor in follicular thyroid cancer through modulating the activities of PI3K/Akt and MAPK/Erk signaling pathways. 28551845 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease HPO
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 AlteredExpression disease BEFREE APP regulation was studied in vitro in differentiated (FRTL-5) and dedifferentiated follicular thyroid carcinomas (FTC-133) thyroid cells after specific inhibition or activation of the cAMP-PKA, the PI3K/AKT or the protein kinase c (PKC) cascades. 18480379 2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.140 AlteredExpression disease BEFREE APP regulation was studied in vitro in differentiated (FRTL-5) and dedifferentiated follicular thyroid carcinomas (FTC-133) thyroid cells after specific inhibition or activation of the cAMP-PKA, the PI3K/AKT or the protein kinase c (PKC) cascades. 18480379 2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.140 GeneticVariation disease BEFREE Substantial improvement in the understanding of the oncogenic pathways in thyroid cancer has led to identification of specific molecular alterations, including mutations of BRAF and RET in papillary thyroid cancer, mutation of RAS and rearrangement of PPARG in follicular thyroid cancer, mutation of RET in medullary thyroid cancer, and mutations of TP53 and in the phosphatidylinositol 3'-kinase (PI3K)/AKT1 pathway in anaplastic thyroid cancer. 27618325 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.140 Biomarker disease BEFREE Similarly, there is increasing evidence demonstrating that mutations leading to activation of the phosphatidylinositol 3- kinase (PI3K)/AKT effectors -PTEN and PI3KCa- are essential for the pathogenesis of follicular thyroid carcinoma (FTC). 18055323 2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.140 Biomarker disease BEFREE Mice with overactivation of the phosphatidylinol-3-kinase (PI3K)-AKT and/or thyrotropin-regulated signaling pathways have been found to develop follicular thyroid cancer. 20001715 2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.140 Biomarker disease HPO
Entrez Id: 9562
Gene Symbol: MINPP1
MINPP1
0.110 GeneticVariation disease BEFREE Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. 11297621 2001
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.110 GeneticVariation disease BEFREE Here, we show SDHD-G12S and SDHD-H50R lead to impaired PTEN function through alteration of its subcellular localization accompanied by resistance to apoptosis and induction of migration in both papillary and follicular thyroid carcinoma cell lines. 25149476 2015
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.110 Biomarker disease HPO
Entrez Id: 9562
Gene Symbol: MINPP1
MINPP1
0.110 Biomarker disease HPO
Entrez Id: 5979
Gene Symbol: RET
RET
0.100 GeneticVariation disease BEFREE This was a retrospective cross-sectional evaluation of 115 archived samples, including: 47 benign (29 follicular adenoma, 11 diffuse hyperplasia, four thyroiditis, and three multinodular goiter), six follicular thyroid carcinomas (FTC), 24 follicular variant of papillary thyroid carcinomas (fvPTC), 27 classic variant of PTC (cPTC), eight diffuse sclerosing variant of PTC (dsvPTC), and three other PTC. 29108474 2018
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.100 GeneticVariation disease BEFREE Several single-nucleotide polymorphisms (SNPs) have been associated with papillary and follicular thyroid cancer (PTC and FTC, respectively) risk, but few have replicated. 27207655 2016
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 AlteredExpression disease BEFREE The data provide strong genetic implication that aberrant activation of PI3K/Akt pathway plays an extensive role in thyroid tumorigenesis, particularly in FTC and ATC, and promotes progression of BTA to FTC and to ATC as the genetic alterations of this pathway accumulate. 17317825 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.100 Biomarker disease BEFREE Mutations in RAS or PAX8/PPARG were exclusive to FTC and fvPTC. 29108474 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.100 AlteredExpression disease BEFREE The data provide strong genetic implication that aberrant activation of PI3K/Akt pathway plays an extensive role in thyroid tumorigenesis, particularly in FTC and ATC, and promotes progression of BTA to FTC and to ATC as the genetic alterations of this pathway accumulate. 17317825 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation disease BEFREE Non-overlapping genetic alterations, including BRAF and RAS point mutations, and RET/PTC and PAX8/PPARγ rearrangements, are found in more than 70% of papillary and follicular thyroid carcinomas. 21739166 2011
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker disease BEFREE Similarly, there is increasing evidence demonstrating that mutations leading to activation of the phosphatidylinositol 3- kinase (PI3K)/AKT effectors -PTEN and PI3KCa- are essential for the pathogenesis of follicular thyroid carcinoma (FTC). 18055323 2007