|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
To our knowledge, this is the first reported case of synchronous and metastatic primary papillary and follicular carcinomas, and the first report of synchronous BRAF V600E mutated papillary and NRAS mutated follicular carcinoma.
|
28710706 |
2018 |
|
rs121913377
|
|
|
0.060 |
GeneticVariation |
BEFREE |
To our knowledge, this is the first reported case of synchronous and metastatic primary papillary and follicular carcinomas, and the first report of synchronous BRAF V600E mutated papillary and NRAS mutated follicular carcinoma.
|
28710706 |
2018 |
|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Unlike BRAF(V600E), the most common mutation, K601E is strongly associated with follicular-patterned cancer, particularly with the encapsulated follicular variant of PTC, and may also be found in follicular thyroid carcinomas.
|
26422023 |
2016 |
|
rs121913377
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Unlike BRAF(V600E), the most common mutation, K601E is strongly associated with follicular-patterned cancer, particularly with the encapsulated follicular variant of PTC, and may also be found in follicular thyroid carcinomas.
|
26422023 |
2016 |
|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
BRAF(V600E) is present in approximately 50% of PTC and also found in aggressive histologic variants and PTC-derived anaplastic thyroid cancer, but is rare in follicular variants, and not found in follicular thyroid cancer.
|
20230995 |
2010 |
|
rs121913377
|
|
|
0.060 |
GeneticVariation |
BEFREE |
BRAF(V600E) is present in approximately 50% of PTC and also found in aggressive histologic variants and PTC-derived anaplastic thyroid cancer, but is rare in follicular variants, and not found in follicular thyroid cancer.
|
20230995 |
2010 |
|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
: The prevalence of BRAF V600E mutation was higher in conventional papillary thyroid cancer (51.0%) than in follicular variant of papillary thyroid cancer (24.1%) and follicular thyroid cancer (1.4%) (P < 0.0001).
|
17717450 |
2007 |
|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
BRAF(V600E) mutation (T1799A) was detected in 5 of 11 cases of PTC and in none of the 5 FTCs.
|
17387744 |
2007 |
|
rs121913377
|
|
|
0.060 |
GeneticVariation |
BEFREE |
: The prevalence of BRAF V600E mutation was higher in conventional papillary thyroid cancer (51.0%) than in follicular variant of papillary thyroid cancer (24.1%) and follicular thyroid cancer (1.4%) (P < 0.0001).
|
17717450 |
2007 |
|
rs121913377
|
|
|
0.060 |
GeneticVariation |
BEFREE |
BRAF(V600E) mutation (T1799A) was detected in 5 of 11 cases of PTC and in none of the 5 FTCs.
|
17387744 |
2007 |
|
rs113488022
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In 137 specimens of FNAB (107 papillary thyroid carcinomas (PTC); 3 follicular thyroid carcinomas (FTC); 2 undifferentiated thyroid carcinomas; 25 benign lesions), both direct DNA sequencing and PCR-RFLP were used for detecting the BRAF(V600E) mutation.
|
17054470 |
2006 |
|
rs121913377
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In 137 specimens of FNAB (107 papillary thyroid carcinomas (PTC); 3 follicular thyroid carcinomas (FTC); 2 undifferentiated thyroid carcinomas; 25 benign lesions), both direct DNA sequencing and PCR-RFLP were used for detecting the BRAF(V600E) mutation.
|
17054470 |
2006 |
|
rs121913364
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Unlike BRAF(V600E), the most common mutation, K601E is strongly associated with follicular-patterned cancer, particularly with the encapsulated follicular variant of PTC, and may also be found in follicular thyroid carcinomas.
|
26422023 |
2016 |
|
rs121913364
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The c.1801A>G mutation was identified in 4 follicular variant papillary carcinomas and one follicular carcinoma.
|
25120313 |
2014 |
|
rs121913364
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The BRAF(K601E) mutation should be included in the spectrum of genetic alterations in FTC.
|
22136270 |
2011 |
|
rs1057519695
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis.
|
28710706 |
2018 |
|
rs1057519834
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis.
|
28710706 |
2018 |
|
rs11554290
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis.
|
28710706 |
2018 |
|
rs1057519695
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequencies of the NRAS(Q61R) in FTAs and FTCs were significantly higher than that in NH (P=.046 and P=.001, respectively).
|
26980032 |
2016 |
|
rs1057519834
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequencies of the NRAS(Q61R) in FTAs and FTCs were significantly higher than that in NH (P=.046 and P=.001, respectively).
|
26980032 |
2016 |
|
rs11554290
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequencies of the NRAS(Q61R) in FTAs and FTCs were significantly higher than that in NH (P=.046 and P=.001, respectively).
|
26980032 |
2016 |
|
rs17849071
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism (SNP) rs17849071 was recently reported to be inversely associated with PIK3CA amplification in follicular thyroid cancer, but the main function of this SNP remains unclear.
|
24908061 |
2014 |
|
rs17849071
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with follicular thyroid cancer and PIK3CA amplification.
|
23185308 |
2012 |
|
rs17849071
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This provides an explanation for the reciprocal relationship of rs17849071G/T with FTC, since PIK3CA amplification is an important oncogenic mechanism in thyroid cancer, particularly FTC.
|
23185308 |
2012 |
|
rs11214077
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we show SDHD-G12S and SDHD-H50R lead to impaired PTEN function through alteration of its subcellular localization accompanied by resistance to apoptosis and induction of migration in both papillary and follicular thyroid carcinoma cell lines.
|
25149476 |
2015 |