Therefore, we also investigated the dynamic of other protein markers involved in cognition and memory impairment such as metabotropic glutamate receptor 5 (mGluR5), ionotropic NMDA receptor (NMDAR2B), prion protein (PrPc) and amyloid precursor protein (APP), whose activity depends on membrane lipid organization.
Moreover, constitutive deletion of the Aβo-binding cellular prion protein (PrP<sup>C</sup>) prevents development of memory deficits in APP<sub>swe</sub>/PS1ΔE9 mice, a model of familial AD.
Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.