Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 GeneticVariation phenotype BEFREE The sensitivities to burning pain and capsaicin of Japanese adult subjects were compared with their TRPV1 genome sequence, and we detected 6 single-nucleotide polymorphisms and 11 single-nucleotide polymorphisms related to burning pain and capsaicin sensitivity, respectively. 30209980 2019
Entrez Id: 2717
Gene Symbol: GLA
GLA 		0.020 GeneticVariation phenotype BEFREE Fabry disease (FD) is an X-linked lysosomal storage disorder that leads to cellular globotriaosylceramide (Gb3) accumulation due to mutations in the gene encoding α-galactosidase A. Trigger-induced acral burning pain is an early FD symptom of unknown pathophysiology. 31778662 2020
Entrez Id: 6335
Gene Symbol: SCN9A
SCN9A 		0.010 GeneticVariation phenotype BEFREE Erythromelalgia due to heterozygous gain-of-function SCN9A mutations usually presents as a pure sensory-autonomic disorder characterized by recurrent episodes of burning pain and redness of the extremities. 23893323 2014
Entrez Id: 2596
Gene Symbol: GAP43
GAP43 		0.010 GeneticVariation phenotype BEFREE Our clinical and skin biopsy study showed that ongoing burning pain was strongly associated with regenerating sprouts, as assessed with GAP43 immunostaining. 29885017 2018
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. 16996476 2006
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. 20422007 2010
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation? 17575321 2007
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype BEFREE Capsaicin is an ingredient in spicy peppers that produces burning pain by activating transient receptor potential vanilloid 1 (TRPV1), a Ca<sup>2+</sup>-permeable ion channel in nociceptors. 28360106 2017
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype BEFREE Such polymodal-sensor aspect makes the TRPV1 channel extremely versatile and important for its role in sensing burning pain. 27038373 2016
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.300 Biomarker phenotype CTD_human Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse. 15996639 2005
Entrez Id: 3231
Gene Symbol: HOXD1
HOXD1 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
Entrez Id: 3827
Gene Symbol: KNG1
KNG1 		0.300 Biomarker phenotype CTD_human Effects of mexiletine on algogenic mediator-induced nociceptive responses in mice. 10445233 1999
Entrez Id: 3269
Gene Symbol: HRH1
HRH1 		0.300 Biomarker phenotype CTD_human Enhanced antinociception by intrathecally-administered morphine in histamine H1 receptor gene knockout mice. 12128009 2002
Entrez Id: 10887
Gene Symbol: PROKR1
PROKR1 		0.300 Biomarker phenotype CTD_human Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. 16793879 2006
Entrez Id: 2643
Gene Symbol: GCH1
GCH1 		0.300 Biomarker phenotype CTD_human Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain. 19081190 2009
Entrez Id: 3827
Gene Symbol: KNG1
KNG1 		0.300 Biomarker phenotype CTD_human Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. 20018876 2010
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human Pain threshold changes in rats following central injection of beta-endorphin, met-enkephalin, vasopressin or oxytocin antisera. 6094376 1984
Entrez Id: 623
Gene Symbol: BDKRB1
BDKRB1 		0.300 Biomarker phenotype CTD_human Kinin B1 receptors contributes to acute pain following minor surgery in humans. 20152050 2010
Entrez Id: 6863
Gene Symbol: TAC1
TAC1 		0.300 Biomarker phenotype CTD_human Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate. 19646975 2009
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human Cortisol, growth hormone response, and pain following tetracosactrin depot and ACTH gel. 4345333 1972
Entrez Id: 1437
Gene Symbol: CSF2
CSF2 		0.300 Biomarker phenotype CTD_human Severe atypical neuropathy associated with administration of hematopoietic colony-stimulating factors and vincristine. 8622042 1996
Entrez Id: 5173
Gene Symbol: PDYN
PDYN 		0.300 Biomarker phenotype CTD_human Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli. 20068450 2010
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human Serum beta-endorphin response to stress before and after operation under fentanyl anesthesia in neonates, infants and preschool children. 20084599 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.300 Biomarker phenotype CTD_human Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. 20383154 2010