Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.100 GeneticVariation phenotype CLINVAR
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.030 Biomarker phenotype BEFREE The objective of the current investigation was to assess the relationship between poor sleep and C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and myeloperoxidase (MPO) in healthy non- and postmenopausal women and men. 31287027 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.030 AlteredExpression phenotype BEFREE Poor sleep quality (PSQI global score) was associated with greater pro-inflammatory cytokine levels: interleukin-1β (IL-1β) (β=0.258, p=0.043), IL-6 (β=0.281, p=0.033), and tumor necrosis factor-alpha (TNF-α) (β=0.263, p=0.044). 28038892 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.030 AlteredExpression phenotype BEFREE Increased BDI-II scores in SAR patients were significantly associated with levels of IL-6 as well as IL-6/IL-10 and IFN-γ/IL-10 ratios and further, to an early age at manifestation of SAR and poor sleep quality. 28495610 2017
Entrez Id: 28954
Gene Symbol: REM1
REM1
0.020 GeneticVariation phenotype BEFREE Girls with RS have poor sleep quality with alterations in slow wave and REM sleep stages. 30262236 2019
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.020 Biomarker phenotype BEFREE In a late-middle-aged at-risk cohort, CRF attenuated the association between poor sleep and levels of select CSF biomarkers. 30958346 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.020 Biomarker phenotype BEFREE The objective of the current investigation was to assess the relationship between poor sleep and C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and myeloperoxidase (MPO) in healthy non- and postmenopausal women and men. 31287027 2019
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.020 Biomarker phenotype BEFREE In a late-middle-aged at-risk cohort, CRF attenuated the association between poor sleep and levels of select CSF biomarkers. 30958346 2019
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.020 Biomarker phenotype BEFREE Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults. 28679595 2017
Entrez Id: 28954
Gene Symbol: REM1
REM1
0.020 GeneticVariation phenotype BEFREE The roles of fear of sleep, REM density, and decreased parasympathetic activity are beginning to inform the relationship between trauma exposure and sleep difficulties. 28828641 2017
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.020 Biomarker phenotype BEFREE Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults. 28679595 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.020 AlteredExpression phenotype BEFREE Poor sleep quality (PSQI global score) was associated with greater pro-inflammatory cytokine levels: interleukin-1β (IL-1β) (β=0.258, p=0.043), IL-6 (β=0.281, p=0.033), and tumor necrosis factor-alpha (TNF-α) (β=0.263, p=0.044). 28038892 2017
Entrez Id: 5673
Gene Symbol: PSG5
PSG5
0.010 Biomarker phenotype BEFREE Several PSG variables that are indicative of sleep fragmentation, sleep disordered breathing, and poor sleep quality correlated with the occurrence of atherosclerosis, but total arousal index was the only independent predictive factor. 29779142 2019
Entrez Id: 57680
Gene Symbol: CHD8
CHD8
0.010 GeneticVariation phenotype BEFREE We investigated 25 individuals with CHD8 protein truncating variants (PTVs), including 10 previously unreported patients and found a male to female ratio of 2.7:1 (19:7) and a pattern of common features: macrocephaly (62.5%), tall stature (47%), developmental delay and/or intellectual disability (81%), ASDs (84%), sleep difficulties (50%), gastrointestinal problems (40%), and distinct facial features. 31001818 2019
Entrez Id: 1446
Gene Symbol: CSN1S1
CSN1S1
0.010 Biomarker phenotype BEFREE This study evaluated the effects of alpha-s1 casein hydrolysate (ACH; Lactium<sup>®</sup>) on the subjective and objective sleep profiles of a community-based sample of Koreans with poor sleep quality. 31252661 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.010 Biomarker phenotype BEFREE Brain-derived neurotrophic factor is a biomarker for subjective insomnia but not objectively assessable poor sleep continuity. 30616157 2019
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
0.010 GeneticVariation phenotype BEFREE While AD may lead to disruption of normal sleep, poor sleep in itself may play a causal role in the development of AD by influencing the production and/or clearance of the amyloid-beta () protein. 31248923 2019
Entrez Id: 5367
Gene Symbol: PMCH
PMCH
0.010 Biomarker phenotype BEFREE When the subjects were divided into quartiles according to WBC count, RBC count, hemoglobin, hematocrit, MCV, MCH, and increased WBC count were associated with smoking, poor sleep, shift work, and obesity. 31241225 2019
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.010 Biomarker phenotype BEFREE The objective of the current investigation was to assess the relationship between poor sleep and C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and myeloperoxidase (MPO) in healthy non- and postmenopausal women and men. 31287027 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.010 Biomarker phenotype BEFREE The objective of the current investigation was to assess the relationship between poor sleep and C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and myeloperoxidase (MPO) in healthy non- and postmenopausal women and men. 31287027 2019
Entrez Id: 1803
Gene Symbol: DPP4
DPP4
0.010 Biomarker phenotype BEFREE DPP-4 Levels Are Increased in Subjects with Poor Sleep Quality. 31355701 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.010 Biomarker phenotype BEFREE Poor sleep quality is similar between early residency cohorts (PGY-1) and later residency cohorts (PGY-3+). 31757438 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.010 Biomarker phenotype BEFREE Poor sleep quality is associated with greater visceral adiposity and leptin secretion. 30098512 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.010 AlteredExpression phenotype BEFREE Poor sleep quality is related to level of asthma control and is associated with COPD groups B and D. 27402309 2018
Entrez Id: 55034
Gene Symbol: MOCOS
MOCOS
0.010 Biomarker phenotype BEFREE Outcomes included mental and physical component summary scores (MCS and PCS) calculated from the Short Form (SF)-36v2 or SF-12v2, SF-6D health utility scores, self-reported psychological complaints (anxiety, depression and sleep difficulties), work productivity and activity impairment, and self-reported healthcare resource utilization. 28898460 2018