Gene: SDHB ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR The effect of some anti-inflammatory agents on elastase release from neutrophils in-vitro. 1980289 1990
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out. 19351833 2009
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD. 19802898 2010
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group BEFREE Eleven out of 14 (79%) patients with PGLs of the organ of Zuckerkandl were found to have mutations in the SDHB (9) or SDHD (2) genes; one patient was found to have the Carney-Stratakis syndrome (CSS), and his PGL was discovered during surgery for gastrointestinal stromal tumor. 20418362 2010
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Genetic testing in pheochromocytoma or functional paraganglioma. 16314641 2005
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group BEFREE Additionally, 36 gastrointestinal stromal tumors (GISTs) were added to explore an association between TERT promoter mutations and SDH deficiency. 24951106 2014
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation. 23282968 2013
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency. 22972948 2012
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas. 12618761 2003
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group BEFREE KIT, PDGFRA, NF1 and SDH mutations are alternate initiating events, fostering hyperplasia in gastrointestinal stromal tumours (GISTs), and additional genetic alterations are required for progression to malignancy. 28270683 2017
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. 14500403 2003
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Genetic testing in head and neck paraganglioma: who, what, and why? 24436918 2013
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. 15328326 2004
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group BEFREE Inactivating mutations of the mitochondrial complex II succinate dehydrogenase (SDH) enzyme subunits SDHB, SDHC, and SDHD are found in PGLs, gain-of-function mutations of c-kit (KIT), and platelet-derived growth factor receptor A (PDGFRA) in GISTs. 17535989 2007
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Germ-line mutations in nonsyndromic pheochromocytoma. 12000816 2002
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group ORPHANET WT GISTs lacking somatic mutations or deletions in SDH subunits had either complete loss of or substantial reduction in SDHB protein expression, whereas most KIT mutant GISTs had strong SDHB expression. 21173220 2011
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group BEFREE Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations. 25188872 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Magnetic resonance imaging spectrum of succinate dehydrogenase-related infantile leukoencephalopathy. 26642834 2016
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR 15 YEARS OF PARAGANGLIOMA: Clinical manifestations of paraganglioma syndromes types 1-5. 26273102 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group LHGDN Familial gastrointestinal stromal tumors and germ-line mutations. 17804857 2007
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Yeast model for evaluating the pathogenic significance of SDHB, SDHC and SDHD mutations in PHEO-PGL syndrome. 23175444 2013
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR How general practitioners manage depressive illness: developing a method of audit. 7143317 1982
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE All nine pediatric/adolescent GISTs and seven adult wild-type GISTs were negative for SDHB immunohistochemistry. 23174939 2013
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group GENOMICS_ENGLAND Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes. 27604308 2016
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE All GISTs from patients with Carney-Stratakis syndrome and Carney triad were negative for SDHB immunohistochemically. 20890271 2011